Cargando…

NIK signaling axis regulates dendritic cell function in intestinal immunity and homeostasis

Dendritic cells (DCs) play an integral role in regulating mucosal immunity and homeostasis, but the signaling network mediating this function of DCs is poorly defined. We identified the noncanonical NF-κB inducing kinase (NIK) as a crucial mediator of mucosal DC function. DC-specific NIK deletion im...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jie, Zuliang, Yang, Jin-Young, Gu, Meidi, Wang, Hui, Xie, Xiaoping, Li, Yanchuan, Liu, Ting, Zhu, Lele, Shi, Jianhong, Zhang, Lingyun, Zhou, Xiaofei, Joo, Donghyun, Brightbill, Hans D, Cong, Yingzi, Lin, Daniel, Cheng, Xuhong, Sun, Shao-Cong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195481/ https://www.ncbi.nlm.nih.gov/pubmed/30250187 http://dx.doi.org/10.1038/s41590-018-0206-z

Ejemplares similares

TBKBP1 and TBK1 form a growth factor signaling axis mediating immunosuppression and tumorigenesis
por: Zhu, Lele, et al.
Publicado: (2019)

Cell intrinsic role of NF-κB-inducing kinase in regulating T cell-mediated immune and autoimmune responses
por: Li, Yanchuan, et al.
Publicado: (2016)

Myeloid cell TBK1 restricts inflammatory responses
por: Gao, Tianxiao, et al.
Publicado: (2022)

TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival
por: Zhu, Lele, et al.
Publicado: (2018)

NF-κB inducing kinase maintains T cell metabolic fitness in antitumor immunity
por: Gu, Meidi, et al.
Publicado: (2021)

Microglia promote autoimmune inflammation via the noncanonical NF-κB pathway
por: Jie, Zuliang, et al.
Publicado: (2021)

Cell type-specific function of TRAF2 and TRAF3 in regulating type I IFN induction
por: Xie, Xiaoping, et al.
Publicado: (2019)

The kinase TBK1 functions in dendritic cells to regulate T cell homeostasis, autoimmunity, and antitumor immunity
por: Xiao, Yichuan, et al.
Publicado: (2017)

TRAF3–EWSR1 signaling axis acts as a checkpoint on germinal center responses
por: Li, Yanchuan, et al.
Publicado: (2023)

Correction: TRAF3–EWSR1 signaling axis acts as a checkpoint on germinal center responses
por: Li, Yanchuan, et al.
Publicado: (2023)

Plug in with Nik software: a photographer's guide to creating dynamic images with Nik software
por: Batdorff, John
Publicado: (2013)

T cell development involves TRAF3IP3-mediated ERK signaling in the Golgi
por: Zou, Qiang, et al.
Publicado: (2015)

A tightly regulated IL-22 response maintains immune functions and homeostasis in systemic viral infection
por: Yi, Panpan, et al.
Publicado: (2017)

The IL32/BAFF axis supports prosurvival dialogs in the lymphoma ecosystem and is disrupted by NIK inhibition
por: Decombis, Salomé, et al.
Publicado: (2022)

NIK signaling in dendritic cells but not in T cells is required for the development of effector T cells and cell-mediated immune responses
por: Hofmann, Janin, et al.
Publicado: (2011)

NF-κB signaling in inflammation
por: Liu, Ting, et al.
Publicado: (2017)

NIK flips the switch on Arp2/3
por: Leslie, Mitch
Publicado: (2015)

Saving β cell function in the NIK of time
por: Tarbell, Kristin V., et al.
Publicado: (2015)

A NIK-SIX signaling axis controls inflammation by targeted silencing of noncanonical NF-κB
por: Liu, Zixu, et al.
Publicado: (2019)

Catalytic subunits of the phosphatase calcineurin interact with NF-κB-inducing kinase (NIK) and attenuate NIK-dependent gene expression
por: Shinzawa, Miho, et al.
Publicado: (2015)

The Therapeutic Potential of Targeting NIK in B Cell Malignancies
por: Haselager, Marco V., et al.
Publicado: (2022)

Metabolic Fire-Up T Cell Induction of Intestinal Inflammation
por: Yang, Wenjing, et al.
Publicado: (2022)

Acute stress disrupts intestinal homeostasis via GDNF‐RET
por: Lin, Lin, et al.
Publicado: (2020)

Glucose promotes regulatory T cell differentiation to maintain intestinal homeostasis
por: Yu, Yu, et al.
Publicado: (2022)

Structural and mechanistic insights into Helicobacter pylori NikR activation
por: Bahlawane, C., et al.
Publicado: (2010)

NIK Stabilization in Osteoclasts Results in Osteoporosis and Enhanced Inflammatory Osteolysis
por: Yang, Chang, et al.
Publicado: (2010)

Dowstream events in the NIK-mediated defense associated with resistance to begomovirus
por: Fontes, Elizabeth
Publicado: (2014)

NIK promotes metabolic adaptation of glioblastoma cells to bioenergetic stress
por: Kamradt, Michael L., et al.
Publicado: (2021)

Conventional Type 1 Dendritic Cells in Intestinal Immune Homeostasis
por: Sasaki, Izumi, et al.
Publicado: (2022)

Crucial roles of XCR1-expressing dendritic cells and the XCR1-XCL1 chemokine axis in intestinal immune homeostasis
por: Ohta, Tomokazu, et al.
Publicado: (2016)

Proinflammatory TLR signaling is regulated by a TRAF2-dependent proteolysis mechanism in macrophages
por: Jin, Jin, et al.
Publicado: (2015)

TPL2 mediates autoimmune inflammation through activation of the TAK1 axis of IL-17 signaling
por: Xiao, Yichuan, et al.
Publicado: (2014)

Intestinal homeostasis and inflammation: Gut microbiota at the crossroads of pancreas–intestinal barrier axis
por: Zhang, Zhongwei, et al.
Publicado: (2022)

TLR5 mediates CD172α(+) intestinal lamina propria dendritic cell induction of Th17 cells
por: Liu, Han, et al.
Publicado: (2016)

SMG1 and NIK regulate apoptosis induced by Smac mimetic compounds
por: Cheung, H H, et al.
Publicado: (2011)

Hierarchical regulation of the NikR-mediated nickel response in Helicobacter pylori
por: Muller, Cécile, et al.
Publicado: (2011)

Biliary NIK promotes ductular reaction and liver injury and fibrosis in mice
por: Zhang, Zhiguo, et al.
Publicado: (2022)

Regulation of Toll-like Receptor 5 Gene Expression and Function on Mucosal Dendritic Cells
por: Feng, Ting, et al.
Publicado: (2012)

APPL1 regulates basal NF-κB activity by stabilizing NIK
por: Hupalowska, Anna, et al.
Publicado: (2012)

Enhanced Adsorption and Recovery of Uranyl Ions by NikR Mutant-Displaying Yeast
por: Kuroda, Kouichi, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_ngd1112a2mgg65l7h8gkedcclt