A functional genetic variation of SLC6A2 repressor hsa-miR-579-3p upregulates sympathetic noradrenergic processes of fear and anxiety

Increased sympathetic noradrenergic signaling is crucially involved in fear and anxiety as defensive states. MicroRNAs regulate dynamic gene expression during synaptic plasticity and genetic variation of microRNAs modulating noradrenaline transporter gene (SLC6A2) expression may thus lead to altered...

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Detalles Bibliográficos
Autores principales: Hommers, L. G., Richter, J., Yang, Y., Raab, A., Baumann, C., Lang, K., Schiele, M. A., Weber, H., Wittmann, A., Wolf, C., Alpers, G. W., Arolt, V., Domschke, K., Fehm, L., Fydrich, T., Gerlach, A., Gloster, A. T., Hamm, A. O., Helbig-Lang, S., Kircher, T., Lang, T., Pané-Farré, C. A., Pauli, P., Pfleiderer, B., Reif, A., Romanos, M., Straube, B., Ströhle, A., Wittchen, H.-U., Frantz, S., Ertl, G., Lohse, M. J., Lueken, U., Deckert, J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195525/
https://www.ncbi.nlm.nih.gov/pubmed/30341278
http://dx.doi.org/10.1038/s41398-018-0278-4

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