Cargando…

Mutational interactions define novel cancer subgroups

Large-scale genomic data highlight the complexity and diversity of the molecular changes that drive cancer progression. Statistical analysis of cancer data from different tissues can guide drug repositioning as well as the design of targeted treatments. Here, we develop an improved Bayesian network...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kuipers, Jack, Thurnherr, Thomas, Moffa, Giusi, Suter, Polina, Behr, Jonas, Goosen, Ryan, Christofori, Gerhard, Beerenwinkel, Niko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195543/ https://www.ncbi.nlm.nih.gov/pubmed/30341300 http://dx.doi.org/10.1038/s41467-018-06867-x

Ejemplares similares

Discovering gene regulatory networks of multiple phenotypic groups using dynamic Bayesian networks
por: Suter, Polina, et al.
Publicado: (2022)

Single-cell mutation calling and phylogenetic tree reconstruction with loss and recurrence
por: Kuipers, Jack, et al.
Publicado: (2022)

Joint inference of exclusivity patterns and recurrent trajectories from tumor mutation trees
por: Luo, Xiang Ge, et al.
Publicado: (2023)

Single-cell mutation identification via phylogenetic inference
por: Singer, Jochen, et al.
Publicado: (2018)

Inferring signalling dynamics by integrating interventional with observational data
por: Cardner, Mathias, et al.
Publicado: (2019)

Longitudinal symptomatic interactions in long-standing schizophrenia: a novel five-point analysis based on directed acyclic graphs
por: Moffa, Giusi, et al.
Publicado: (2023)

Single-cell sequencing data reveal widespread recurrence and loss of mutational hits in the life histories of tumors
por: Kuipers, Jack, et al.
Publicado: (2017)

COMPASS: joint copy number and mutation phylogeny reconstruction from amplicon single-cell sequencing data
por: Sollier, Etienne, et al.
Publicado: (2023)

Genomic variant annotation workflow for clinical applications
por: Thurnherr, Thomas, et al.
Publicado: (2016)

Tree inference for single-cell data
por: Jahn, Katharina, et al.
Publicado: (2016)

Advances in understanding tumour evolution through single-cell sequencing()
por: Kuipers, Jack, et al.
Publicado: (2017)

Multi-omics subtyping of hepatocellular carcinoma patients using a Bayesian network mixture model
por: Suter, Polina, et al.
Publicado: (2022)

Detailed simulation of cancer exome sequencing data reveals differences and common limitations of variant callers
por: Hofmann, Ariane L., et al.
Publicado: (2017)

Hierarchy of TGFβ/SMAD, Hippo/YAP/TAZ, and Wnt/β-catenin signaling in melanoma phenotype switching
por: Lüönd, Fabiana, et al.
Publicado: (2021)

Predicting colorectal cancer risk from adenoma detection via a two-type branching process model
por: Lang, Brian M., et al.
Publicado: (2020)

Integrative inference of subclonal tumour evolution from single-cell and bulk sequencing data
por: Malikic, Salem, et al.
Publicado: (2019)

Single-cell phylogenies reveal changes in the evolutionary rate within cancer and healthy tissues
por: Borgsmüller, Nico, et al.
Publicado: (2023)

Modeling Mutual Exclusivity of Cancer Mutations
por: Szczurek, Ewa, et al.
Publicado: (2014)

Spatial Distribution of Private Gene Mutations in Clear Cell Renal Cell Carcinoma
por: Moore, Ariane L., et al.
Publicado: (2021)

Comparing mutational pathways to lopinavir resistance in HIV-1 subtypes B versus C
por: Posada-Céspedes, Susana, et al.
Publicado: (2021)

Using Directed Acyclic Graphs in Epidemiological Research in Psychosis: An Analysis of the Role of Bullying in Psychosis
por: Moffa, Giusi, et al.
Publicado: (2017)

Targeting Metabolic Symbiosis to Overcome Resistance to Anti-angiogenic Therapy
por: Pisarsky, Laura, et al.
Publicado: (2016)

Clonal evolution driven by superdriver mutations
por: Grossmann, Patrick, et al.
Publicado: (2020)

The Bourque distances for mutation trees of cancers
por: Jahn, Katharina, et al.
Publicado: (2021)

Improved pathway reconstruction from RNA interference screens by exploiting off-target effects
por: Srivatsa, Sumana, et al.
Publicado: (2018)

Identification of Constrained Cancer Driver Genes Based on Mutation Timing
por: Sakoparnig, Thomas, et al.
Publicado: (2015)

Mutational signatures in esophageal adenocarcinoma define etiologically distinct subgroups with therapeutic relevance
por: Secrier, Maria, et al.
Publicado: (2016)

Computational Model Reveals a Stochastic Mechanism behind Germinal Center Clonal Bursts
por: Pélissier, Aurélien, et al.
Publicado: (2020)

Integrated genetic and epigenetic analysis defines novel molecular subgroups in rhabdomyosarcoma
por: Seki, Masafumi, et al.
Publicado: (2015)

HRAS Mutations Define a Distinct Subgroup in Head and Neck Squamous Cell Carcinoma
por: Coleman, Niamh, et al.
Publicado: (2023)

Novel mutations target distinct subgroups of medulloblastoma
por: Robinson, Giles, et al.
Publicado: (2012)

Inferring genetic interactions from comparative fitness data
por: Crona, Kristina, et al.
Publicado: (2017)

Network-based integration of multi-omics data for prioritizing cancer genes
por: Dimitrakopoulos, Christos, et al.
Publicado: (2018)

Clinically and biologically relevant subgroups of Wilms tumour defined by genomic and epigenomic analyses
por: Brzezinski, Jack, et al.
Publicado: (2020)

Functionally and medically defined subgroups of nursing home populations
por: Manton, Kenneth G., et al.
Publicado: (1990)

Molecular subtyping for clinically defined breast cancer subgroups
por: Zhao, Xi, et al.
Publicado: (2015)

Transcriptomes define distinct subgroups of salivary gland adenoid cystic carcinoma with different driver mutations and outcomes
por: Frerich, Candace A., et al.
Publicado: (2017)

Glycolysis Define Two Prognostic Subgroups of Lung Adenocarcinoma With Different Mutation Characteristics and Immune Infiltration Signatures
por: Huo, Chen, et al.
Publicado: (2021)

NGS-pipe: a flexible, easily extendable and highly configurable framework for NGS analysis
por: Singer, Jochen, et al.
Publicado: (2018)

The geometry of partial fitness orders and an efficient method for detecting genetic interactions
por: Lienkaemper, Caitlin, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_pdh9chphk6171ka81k9hvqatvf