Neurokinin-3 receptor activation selectively prolongs atrial refractoriness by inhibition of a background K(+) channel

The cardiac autonomic nervous system (ANS) controls normal atrial electrical function. The cardiac ANS produces various neuropeptides, among which the neurokinins, whose actions on atrial electrophysiology are largely unknown. We here demonstrate that the neurokinin substance-P (Sub-P) activates a n...

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Detalles Bibliográficos
Autores principales: Veldkamp, Marieke W., Geuzebroek, Guillaume S. C., Baartscheer, Antonius, Verkerk, Arie O., Schumacher, Cees A., Suarez, Gedeon G., Berger, Wouter R., Casini, Simona, van Amersfoorth, Shirley C. M., Scholman, Koen T., Driessen, Antoine H. G., Belterman, Charly N. W., van Ginneken, Antoni C. G., de Groot, Joris R., de Bakker, Jacques M. T., Remme, Carol Ann, Boukens, Bas J., Coronel, Ruben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195571/
https://www.ncbi.nlm.nih.gov/pubmed/30341287
http://dx.doi.org/10.1038/s41467-018-06530-5

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