HSP90-incorporating chaperome networks as biosensor for disease-related pathways in patient-specific midbrain dopamine neurons

Environmental and genetic risk factors contribute to Parkinson’s Disease (PD) pathogenesis and the associated midbrain dopamine (mDA) neuron loss. Here, we identify early PD pathogenic events by developing methodology that utilizes recent innovations in human pluripotent stem cells (hPSC) and chemic...

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Detalles Bibliográficos
Autores principales: Kishinevsky, Sarah, Wang, Tai, Rodina, Anna, Chung, Sun Young, Xu, Chao, Philip, John, Taldone, Tony, Joshi, Suhasini, Alpaugh, Mary L., Bolaender, Alexander, Gutbier, Simon, Sandhu, Davinder, Fattahi, Faranak, Zimmer, Bastian, Shah, Smit K., Chang, Elizabeth, Inda, Carmen, Koren, John, Saurat, Nathalie G., Leist, Marcel, Gross, Steven S., Seshan, Venkatraman E., Klein, Christine, Tomishima, Mark J., Erdjument-Bromage, Hediye, Neubert, Thomas A., Henrickson, Ronald C., Chiosis, Gabriela, Studer, Lorenz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195591/
https://www.ncbi.nlm.nih.gov/pubmed/30341316
http://dx.doi.org/10.1038/s41467-018-06486-6

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