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The role of mTOR-mediated signals during haemopoiesis and lineage commitment

The serine/threonine protein kinase mechanistic target of rapamycin (mTOR) has been implicated in the regulation of an array of cellular functions including protein and lipid synthesis, proliferation, cell size and survival. Here, we describe the role of mTOR during haemopoiesis within the context o...

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Detalles Bibliográficos
Autores principales: Malik, Natasha, Sansom, Owen J., Michie, Alison M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195642/
https://www.ncbi.nlm.nih.gov/pubmed/30154096
http://dx.doi.org/10.1042/BST20180141
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author Malik, Natasha
Sansom, Owen J.
Michie, Alison M.
author_facet Malik, Natasha
Sansom, Owen J.
Michie, Alison M.
author_sort Malik, Natasha
collection PubMed
description The serine/threonine protein kinase mechanistic target of rapamycin (mTOR) has been implicated in the regulation of an array of cellular functions including protein and lipid synthesis, proliferation, cell size and survival. Here, we describe the role of mTOR during haemopoiesis within the context of mTORC1 and mTORC2, the distinct complexes in which it functions. The use of conditional transgenic mouse models specifically targeting individual mTOR signalling components, together with selective inhibitors, have generated a significant body of research emphasising the critical roles played by mTOR, and individual mTOR complexes, in haemopoietic lineage commitment and development. This review will describe the profound role of mTOR in embryogenesis and haemopoiesis, underscoring the importance of mTORC1 at the early stages of haemopoietic cell development, through modulation of stem cell potentiation and self-renewal, and erythroid and B cell lineage commitment. Furthermore, the relatively discrete role of mTORC2 in haemopoiesis will be explored during T cell development and B cell maturation. Collectively, this review aims to highlight the functional diversity of mTOR signalling and underline the importance of this pathway in haemopoiesis.
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spelling pubmed-61956422018-10-30 The role of mTOR-mediated signals during haemopoiesis and lineage commitment Malik, Natasha Sansom, Owen J. Michie, Alison M. Biochem Soc Trans Review Articles The serine/threonine protein kinase mechanistic target of rapamycin (mTOR) has been implicated in the regulation of an array of cellular functions including protein and lipid synthesis, proliferation, cell size and survival. Here, we describe the role of mTOR during haemopoiesis within the context of mTORC1 and mTORC2, the distinct complexes in which it functions. The use of conditional transgenic mouse models specifically targeting individual mTOR signalling components, together with selective inhibitors, have generated a significant body of research emphasising the critical roles played by mTOR, and individual mTOR complexes, in haemopoietic lineage commitment and development. This review will describe the profound role of mTOR in embryogenesis and haemopoiesis, underscoring the importance of mTORC1 at the early stages of haemopoietic cell development, through modulation of stem cell potentiation and self-renewal, and erythroid and B cell lineage commitment. Furthermore, the relatively discrete role of mTORC2 in haemopoiesis will be explored during T cell development and B cell maturation. Collectively, this review aims to highlight the functional diversity of mTOR signalling and underline the importance of this pathway in haemopoiesis. Portland Press Ltd. 2018-10-19 2018-08-28 /pmc/articles/PMC6195642/ /pubmed/30154096 http://dx.doi.org/10.1042/BST20180141 Text en © 2018 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Articles
Malik, Natasha
Sansom, Owen J.
Michie, Alison M.
The role of mTOR-mediated signals during haemopoiesis and lineage commitment
title The role of mTOR-mediated signals during haemopoiesis and lineage commitment
title_full The role of mTOR-mediated signals during haemopoiesis and lineage commitment
title_fullStr The role of mTOR-mediated signals during haemopoiesis and lineage commitment
title_full_unstemmed The role of mTOR-mediated signals during haemopoiesis and lineage commitment
title_short The role of mTOR-mediated signals during haemopoiesis and lineage commitment
title_sort role of mtor-mediated signals during haemopoiesis and lineage commitment
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195642/
https://www.ncbi.nlm.nih.gov/pubmed/30154096
http://dx.doi.org/10.1042/BST20180141
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