Rare gene fusion rearrangement SPTNB1-PDGFRB in an atypical myeloproliferative neoplasm

The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia recognizes a distinct class of myeloid and lymphoid tumors with eosinophilia-related proliferations associated with specific gene rearrangements, one of which involves rearrangements of platelet...

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Detalles Bibliográficos
Autores principales: Furtado, Vanessa Fiorini, Saini, Neeraj Y., Walsh, William, Bathini, Venu, Miron, Patricia M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Letter to Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195751/
https://www.ncbi.nlm.nih.gov/pubmed/30377450
http://dx.doi.org/10.1186/s13039-018-0405-1
Descripción
Sumario:The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia recognizes a distinct class of myeloid and lymphoid tumors with eosinophilia-related proliferations associated with specific gene rearrangements, one of which involves rearrangements of platelet-derived growth factor receptor B (PDGFRB) gene. We report a case of a rare PDGFRB rearrangement with SPTNB1 (spectrin beta, nonerythrocytic 1) that presented as atypical myeloproliferative neoplasm.

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