Rare gene fusion rearrangement SPTNB1-PDGFRB in an atypical myeloproliferative neoplasm

The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia recognizes a distinct class of myeloid and lymphoid tumors with eosinophilia-related proliferations associated with specific gene rearrangements, one of which involves rearrangements of platelet...

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Autores principales: Furtado, Vanessa Fiorini, Saini, Neeraj Y., Walsh, William, Bathini, Venu, Miron, Patricia M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Letter to Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195751/
https://www.ncbi.nlm.nih.gov/pubmed/30377450
http://dx.doi.org/10.1186/s13039-018-0405-1
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author Furtado, Vanessa Fiorini
Saini, Neeraj Y.
Walsh, William
Bathini, Venu
Miron, Patricia M.
author_facet Furtado, Vanessa Fiorini
Saini, Neeraj Y.
Walsh, William
Bathini, Venu
Miron, Patricia M.
author_sort Furtado, Vanessa Fiorini
collection PubMed
description The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia recognizes a distinct class of myeloid and lymphoid tumors with eosinophilia-related proliferations associated with specific gene rearrangements, one of which involves rearrangements of platelet-derived growth factor receptor B (PDGFRB) gene. We report a case of a rare PDGFRB rearrangement with SPTNB1 (spectrin beta, nonerythrocytic 1) that presented as atypical myeloproliferative neoplasm.
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spelling pubmed-61957512018-10-30 Rare gene fusion rearrangement SPTNB1-PDGFRB in an atypical myeloproliferative neoplasm Furtado, Vanessa Fiorini Saini, Neeraj Y. Walsh, William Bathini, Venu Miron, Patricia M. Mol Cytogenet Letter to Editor The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia recognizes a distinct class of myeloid and lymphoid tumors with eosinophilia-related proliferations associated with specific gene rearrangements, one of which involves rearrangements of platelet-derived growth factor receptor B (PDGFRB) gene. We report a case of a rare PDGFRB rearrangement with SPTNB1 (spectrin beta, nonerythrocytic 1) that presented as atypical myeloproliferative neoplasm. BioMed Central 2018-10-19 /pmc/articles/PMC6195751/ /pubmed/30377450 http://dx.doi.org/10.1186/s13039-018-0405-1 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Letter to Editor
Furtado, Vanessa Fiorini
Saini, Neeraj Y.
Walsh, William
Bathini, Venu
Miron, Patricia M.
Rare gene fusion rearrangement SPTNB1-PDGFRB in an atypical myeloproliferative neoplasm
title Rare gene fusion rearrangement SPTNB1-PDGFRB in an atypical myeloproliferative neoplasm
title_full Rare gene fusion rearrangement SPTNB1-PDGFRB in an atypical myeloproliferative neoplasm
title_fullStr Rare gene fusion rearrangement SPTNB1-PDGFRB in an atypical myeloproliferative neoplasm
title_full_unstemmed Rare gene fusion rearrangement SPTNB1-PDGFRB in an atypical myeloproliferative neoplasm
title_short Rare gene fusion rearrangement SPTNB1-PDGFRB in an atypical myeloproliferative neoplasm
title_sort rare gene fusion rearrangement sptnb1-pdgfrb in an atypical myeloproliferative neoplasm
topic Letter to Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195751/
https://www.ncbi.nlm.nih.gov/pubmed/30377450
http://dx.doi.org/10.1186/s13039-018-0405-1
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