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Reduction of SIRT1 epigenetically upregulates NALP1 expression and contributes to neuropathic pain induced by chemotherapeutic drug bortezomib

BACKGROUND: Bortezomib is a frequently used chemotherapeutic drug for the treatment of multiple myeloma and other nonsolid malignancies. Accumulating evidence has demonstrated that bortezomib-induced persistent pain serves as the most frequent reason for treatment discontinuation. METHODS: The von F...

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Detalles Bibliográficos
Autores principales:	Chen, Kun, Fan, Jing, Luo, Zhao-Fan, Yang, Ying, Xin, Wen-Jun, Liu, Cui-Cui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195754/ https://www.ncbi.nlm.nih.gov/pubmed/30342528 http://dx.doi.org/10.1186/s12974-018-1327-x

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