miR-30 Disrupts Senescence and Promotes Cancer by Targeting both p16(INK4A) and DNA Damage Pathways

miR-30 is a microRNA frequently overexpressed in human cancers. However, the biological consequence of miR-30 overexpression in cancer has been unclear. In a genetic screen, miR-30 was found to abrogate oncogenic-induced senescence, a key tumor-suppressing mechanism that involves DNA damage response...

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Detalles Bibliográficos
Autores principales: Su, Weijun, Hong, Lixin, Xu, Xin, Huang, Shan, Herpai, Denise, Li, Lisheng, Xu, Yingxi, Truong, Lan, Hu, Wen-Yuan, Wu, Xiaohua, Xiao, Changchun, Zhang, Wei, Han, Jiahuai, Debinski, Waldemar, Xiang, Rong, Sun, Peiqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195819/
https://www.ncbi.nlm.nih.gov/pubmed/29907771
http://dx.doi.org/10.1038/s41388-018-0358-1

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