A platform of genetically engineered bacteria as vehicles for localized delivery of therapeutics: Toward applications for Crohn's disease

For therapies targeting diseases of the gastrointestinal tract, we and others envision probiotic bacteria that synthesize and excrete biotherapeutics at disease sites. Toward this goal, we have engineered commensal E. coli that selectively synthesize and secrete a model biotherapeutic in the presenc...

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Detalles Bibliográficos
Autores principales: McKay, Ryan, Ghodasra, Monil, Schardt, John, Quan, David, Pottash, Alex Eli, Shang, Wu, Jay, Steven M., Payne, Gregory F., Chang, Matthew Wook, March, John C., Bentley, William E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2018
Materias:
Research Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195910/
https://www.ncbi.nlm.nih.gov/pubmed/30377661
http://dx.doi.org/10.1002/btm2.10113

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