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Incidence of tuberculosis in children on antiretroviral therapy: a retrospective cohort study
OBJECTIVES: Be aware of the burden of tuberculosis among high-risk population is important. Three hundred fifty-two children were participated in this study. Survival analysis was conducted. We assessed the incidence of tuberculosis and its predictors in children on ART. RESULTS: Tuberculosis incide...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195951/ https://www.ncbi.nlm.nih.gov/pubmed/30342550 http://dx.doi.org/10.1186/s13104-018-3846-z |
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author | Endalamaw, Aklilu Engeda, Eshetu Hailesilassie Tezera, Nega |
author_facet | Endalamaw, Aklilu Engeda, Eshetu Hailesilassie Tezera, Nega |
author_sort | Endalamaw, Aklilu |
collection | PubMed |
description | OBJECTIVES: Be aware of the burden of tuberculosis among high-risk population is important. Three hundred fifty-two children were participated in this study. Survival analysis was conducted. We assessed the incidence of tuberculosis and its predictors in children on ART. RESULTS: Tuberculosis incidence rate in children on ART was 2.63 per 100 person-years. Those children who were on baseline World Health Organization clinical stages 3 and 4 (AHR (adjusted hazard ratio) = 3.0; 95% CI 1.2–7.7), “fair” and “poor” ART adherence (AHR = 4.0; 95% CI 1.5–10.8), late initiation of ART (AHR = 4.0; 95% CI 1.5–10.6), and less than 6 months duration on ART (AHR = 5.5; 95% CI 1.5–20.6) were more likely to develop tuberculosis infection. The incidence rate of TB in children on ART was high. This study suggests a need to give attention to advanced AIDS stages and improve timely initiation of ART and level of adherence to ART. |
format | Online Article Text |
id | pubmed-6195951 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-61959512018-10-30 Incidence of tuberculosis in children on antiretroviral therapy: a retrospective cohort study Endalamaw, Aklilu Engeda, Eshetu Hailesilassie Tezera, Nega BMC Res Notes Research Note OBJECTIVES: Be aware of the burden of tuberculosis among high-risk population is important. Three hundred fifty-two children were participated in this study. Survival analysis was conducted. We assessed the incidence of tuberculosis and its predictors in children on ART. RESULTS: Tuberculosis incidence rate in children on ART was 2.63 per 100 person-years. Those children who were on baseline World Health Organization clinical stages 3 and 4 (AHR (adjusted hazard ratio) = 3.0; 95% CI 1.2–7.7), “fair” and “poor” ART adherence (AHR = 4.0; 95% CI 1.5–10.8), late initiation of ART (AHR = 4.0; 95% CI 1.5–10.6), and less than 6 months duration on ART (AHR = 5.5; 95% CI 1.5–20.6) were more likely to develop tuberculosis infection. The incidence rate of TB in children on ART was high. This study suggests a need to give attention to advanced AIDS stages and improve timely initiation of ART and level of adherence to ART. BioMed Central 2018-10-20 /pmc/articles/PMC6195951/ /pubmed/30342550 http://dx.doi.org/10.1186/s13104-018-3846-z Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Note Endalamaw, Aklilu Engeda, Eshetu Hailesilassie Tezera, Nega Incidence of tuberculosis in children on antiretroviral therapy: a retrospective cohort study |
title | Incidence of tuberculosis in children on antiretroviral therapy: a retrospective cohort study |
title_full | Incidence of tuberculosis in children on antiretroviral therapy: a retrospective cohort study |
title_fullStr | Incidence of tuberculosis in children on antiretroviral therapy: a retrospective cohort study |
title_full_unstemmed | Incidence of tuberculosis in children on antiretroviral therapy: a retrospective cohort study |
title_short | Incidence of tuberculosis in children on antiretroviral therapy: a retrospective cohort study |
title_sort | incidence of tuberculosis in children on antiretroviral therapy: a retrospective cohort study |
topic | Research Note |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195951/ https://www.ncbi.nlm.nih.gov/pubmed/30342550 http://dx.doi.org/10.1186/s13104-018-3846-z |
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