Cargando…
Association between sickle cell disease and the oral health condition of children and adolescents
BACKGROUND: Sickle cell disease (SCD) is the most prevalent monogenic hereditary pathology associated with the presence of hemoglobin SS in the world. It can affect individuals, leading to changes in the face and body, causing a deficiency in dental and bone tissue formation that can ultimately resu...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196017/ https://www.ncbi.nlm.nih.gov/pubmed/30342522 http://dx.doi.org/10.1186/s12903-018-0629-9 |
_version_ | 1783364498159042560 |
---|---|
author | Brandão, Carla Figueiredo Oliveira, Viviane Maia Barreto Santos, Ada Rocha Ramony Martins da Silva, Taísa Midlej Martins Vilella, Verônica Queiroz Cruz Simas, Gleice Glenda Prata Pimentel Carvalho, Laura Regina Santos Carvalho, Raissa Aires Costa Ladeia, Ana Marice Teixeira |
author_facet | Brandão, Carla Figueiredo Oliveira, Viviane Maia Barreto Santos, Ada Rocha Ramony Martins da Silva, Taísa Midlej Martins Vilella, Verônica Queiroz Cruz Simas, Gleice Glenda Prata Pimentel Carvalho, Laura Regina Santos Carvalho, Raissa Aires Costa Ladeia, Ana Marice Teixeira |
author_sort | Brandão, Carla Figueiredo |
collection | PubMed |
description | BACKGROUND: Sickle cell disease (SCD) is the most prevalent monogenic hereditary pathology associated with the presence of hemoglobin SS in the world. It can affect individuals, leading to changes in the face and body, causing a deficiency in dental and bone tissue formation that can ultimately result in a higher level of predisposition to developing dental caries. This study aimed to evaluate the oral condition of children and adolescents with SCD in comparison with the condition of healthy controls. METHODS: This was a cross-sectional study of children and adolescents aged 5 to 18 of both sexes from a hematology center in Bahia, Brazil, and subjects without hemoglobinopathies from a public school of the same state (comparison group). There were 124 individuals, 63 in the comparison group and 61 in the disease group. Interviews, dental and periodontal exams using the DMFT and Periodontal Community Index, respectively, were performed, and the salivary buffer capacity and salivary flow rates of the entire sample population were evaluated. The categorical variables were compared using a chi-square test or Fisher’s exact test. For comparison of means, the Student’s-t test was used for independent samples that presented symmetrical distribution. RESULTS: The study showed that the DMFT was 2.08 (2.71) for the SCD group and 1.05 (1.67) for the comparison group (p = 0.013). For dmft, the values were 2.3 (2.6) and 0.88 (1.2), respectively, (p = 0.018). Exams of the periodontium showed the presence of gingival bleeding and dental calculus, with no statistical significance between groups (p = 0.984). When evaluating salivary flow and buffer capacity, no significant differences were observed for the flow rates (p = 0.485), but the SCD group presented a lower buffer capacity compared with the comparison group (p = 0.006). Individuals who used hydroxyurea had a dmft (2.50) higher than that of the comparison group (2.00), and salivary flow was lower than the normal rate in 70% of the children who did not use this medication. CONCLUSION: Children and teenagers with SCD had deficient oral health when compared with the comparison group, presenting a higher level of dental caries and lower buffer capacity. |
format | Online Article Text |
id | pubmed-6196017 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-61960172018-10-30 Association between sickle cell disease and the oral health condition of children and adolescents Brandão, Carla Figueiredo Oliveira, Viviane Maia Barreto Santos, Ada Rocha Ramony Martins da Silva, Taísa Midlej Martins Vilella, Verônica Queiroz Cruz Simas, Gleice Glenda Prata Pimentel Carvalho, Laura Regina Santos Carvalho, Raissa Aires Costa Ladeia, Ana Marice Teixeira BMC Oral Health Research Article BACKGROUND: Sickle cell disease (SCD) is the most prevalent monogenic hereditary pathology associated with the presence of hemoglobin SS in the world. It can affect individuals, leading to changes in the face and body, causing a deficiency in dental and bone tissue formation that can ultimately result in a higher level of predisposition to developing dental caries. This study aimed to evaluate the oral condition of children and adolescents with SCD in comparison with the condition of healthy controls. METHODS: This was a cross-sectional study of children and adolescents aged 5 to 18 of both sexes from a hematology center in Bahia, Brazil, and subjects without hemoglobinopathies from a public school of the same state (comparison group). There were 124 individuals, 63 in the comparison group and 61 in the disease group. Interviews, dental and periodontal exams using the DMFT and Periodontal Community Index, respectively, were performed, and the salivary buffer capacity and salivary flow rates of the entire sample population were evaluated. The categorical variables were compared using a chi-square test or Fisher’s exact test. For comparison of means, the Student’s-t test was used for independent samples that presented symmetrical distribution. RESULTS: The study showed that the DMFT was 2.08 (2.71) for the SCD group and 1.05 (1.67) for the comparison group (p = 0.013). For dmft, the values were 2.3 (2.6) and 0.88 (1.2), respectively, (p = 0.018). Exams of the periodontium showed the presence of gingival bleeding and dental calculus, with no statistical significance between groups (p = 0.984). When evaluating salivary flow and buffer capacity, no significant differences were observed for the flow rates (p = 0.485), but the SCD group presented a lower buffer capacity compared with the comparison group (p = 0.006). Individuals who used hydroxyurea had a dmft (2.50) higher than that of the comparison group (2.00), and salivary flow was lower than the normal rate in 70% of the children who did not use this medication. CONCLUSION: Children and teenagers with SCD had deficient oral health when compared with the comparison group, presenting a higher level of dental caries and lower buffer capacity. BioMed Central 2018-10-20 /pmc/articles/PMC6196017/ /pubmed/30342522 http://dx.doi.org/10.1186/s12903-018-0629-9 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Brandão, Carla Figueiredo Oliveira, Viviane Maia Barreto Santos, Ada Rocha Ramony Martins da Silva, Taísa Midlej Martins Vilella, Verônica Queiroz Cruz Simas, Gleice Glenda Prata Pimentel Carvalho, Laura Regina Santos Carvalho, Raissa Aires Costa Ladeia, Ana Marice Teixeira Association between sickle cell disease and the oral health condition of children and adolescents |
title | Association between sickle cell disease and the oral health condition of children and adolescents |
title_full | Association between sickle cell disease and the oral health condition of children and adolescents |
title_fullStr | Association between sickle cell disease and the oral health condition of children and adolescents |
title_full_unstemmed | Association between sickle cell disease and the oral health condition of children and adolescents |
title_short | Association between sickle cell disease and the oral health condition of children and adolescents |
title_sort | association between sickle cell disease and the oral health condition of children and adolescents |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196017/ https://www.ncbi.nlm.nih.gov/pubmed/30342522 http://dx.doi.org/10.1186/s12903-018-0629-9 |
work_keys_str_mv | AT brandaocarlafigueiredo associationbetweensicklecelldiseaseandtheoralhealthconditionofchildrenandadolescents AT oliveiravivianemaiabarreto associationbetweensicklecelldiseaseandtheoralhealthconditionofchildrenandadolescents AT santosadarocharamonymartins associationbetweensicklecelldiseaseandtheoralhealthconditionofchildrenandadolescents AT dasilvataisamidlejmartins associationbetweensicklecelldiseaseandtheoralhealthconditionofchildrenandadolescents AT vilellaveronicaqueirozcruz associationbetweensicklecelldiseaseandtheoralhealthconditionofchildrenandadolescents AT simasgleiceglendapratapimentel associationbetweensicklecelldiseaseandtheoralhealthconditionofchildrenandadolescents AT carvalholaurareginasantos associationbetweensicklecelldiseaseandtheoralhealthconditionofchildrenandadolescents AT carvalhoraissaairescosta associationbetweensicklecelldiseaseandtheoralhealthconditionofchildrenandadolescents AT ladeiaanamariceteixeira associationbetweensicklecelldiseaseandtheoralhealthconditionofchildrenandadolescents |