The Chlamydia M278 Major Outer Membrane Peptide Encapsulated in the Poly(lactic acid)-Poly(ethylene glycol) Nanoparticulate Self-Adjuvanting Delivery System Protects Mice Against a Chlamydia muridarum Genital Tract Challenge by Stimulating Robust Systemic and Local Mucosal Immune Responses

Recently, we reported that our PPM chlamydial nanovaccine [a biodegradable co-polymeric PLA-PEG (poly(lactic acid)-poly(ethylene glycol))-encapsulated M278 peptide (derived from the major outer membrane protein (MOMP) of Chlamydia)] exploits the caveolin-mediated endocytosis pathway for endosomal pr...

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Detalles Bibliográficos
Autores principales: Verma, Richa, Sahu, Rajnish, Dixit, Saurabh, Duncan, Skyla A., Giambartolomei, Guillermo H., Singh, Shree R., Dennis, Vida A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196261/
https://www.ncbi.nlm.nih.gov/pubmed/30374357
http://dx.doi.org/10.3389/fimmu.2018.02369

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