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The Rules of Attraction in Central Nervous System Myelination

The wrapping of myelin around axons is crucial for the development and function of the central nervous system (CNS) of vertebrates, greatly regulating the conduction of action potentials. Oligodendrocytes, the myelinating glia of the CNS, have an intrinsic tendency to wrap myelin around any permissi...

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Autor principal: Almeida, Rafael Góis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196289/
https://www.ncbi.nlm.nih.gov/pubmed/30374292
http://dx.doi.org/10.3389/fncel.2018.00367
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author Almeida, Rafael Góis
author_facet Almeida, Rafael Góis
author_sort Almeida, Rafael Góis
collection PubMed
description The wrapping of myelin around axons is crucial for the development and function of the central nervous system (CNS) of vertebrates, greatly regulating the conduction of action potentials. Oligodendrocytes, the myelinating glia of the CNS, have an intrinsic tendency to wrap myelin around any permissive structure in vitro, but in vivo, myelin is targeted with remarkable specificity only to certain axons. Despite the importance of myelination, the mechanisms by which oligodendrocytes navigate a complex milieu that includes many types of cells and their cellular projections and select only certain axons for myelination remains incompletely understood. In this Mini-review, I highlight recent studies that shed light on the molecular and cellular rules governing CNS myelin targeting.
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spelling pubmed-61962892018-10-29 The Rules of Attraction in Central Nervous System Myelination Almeida, Rafael Góis Front Cell Neurosci Cellular Neuroscience The wrapping of myelin around axons is crucial for the development and function of the central nervous system (CNS) of vertebrates, greatly regulating the conduction of action potentials. Oligodendrocytes, the myelinating glia of the CNS, have an intrinsic tendency to wrap myelin around any permissive structure in vitro, but in vivo, myelin is targeted with remarkable specificity only to certain axons. Despite the importance of myelination, the mechanisms by which oligodendrocytes navigate a complex milieu that includes many types of cells and their cellular projections and select only certain axons for myelination remains incompletely understood. In this Mini-review, I highlight recent studies that shed light on the molecular and cellular rules governing CNS myelin targeting. Frontiers Media S.A. 2018-10-15 /pmc/articles/PMC6196289/ /pubmed/30374292 http://dx.doi.org/10.3389/fncel.2018.00367 Text en Copyright © 2018 Almeida. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular Neuroscience
Almeida, Rafael Góis
The Rules of Attraction in Central Nervous System Myelination
title The Rules of Attraction in Central Nervous System Myelination
title_full The Rules of Attraction in Central Nervous System Myelination
title_fullStr The Rules of Attraction in Central Nervous System Myelination
title_full_unstemmed The Rules of Attraction in Central Nervous System Myelination
title_short The Rules of Attraction in Central Nervous System Myelination
title_sort rules of attraction in central nervous system myelination
topic Cellular Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196289/
https://www.ncbi.nlm.nih.gov/pubmed/30374292
http://dx.doi.org/10.3389/fncel.2018.00367
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