Pleiotropic Impacts of Macrophage and Microglial Deficiency on Development in Rats with Targeted Mutation of the Csf1r Locus

We have produced Csf1r-deficient rats by homologous recombination in embryonic stem cells. Consistent with the role of Csf1r in macrophage differentiation, there was a loss of peripheral blood monocytes, microglia in the brain, epidermal Langerhans cells, splenic marginal zone macrophages, bone-asso...

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Detalles Bibliográficos
Autores principales: Pridans, Clare, Raper, Anna, Davis, Gemma M., Alves, Joana, Sauter, Kristin A., Lefevre, Lucas, Regan, Tim, Meek, Stephen, Sutherland, Linda, Thomson, Alison J., Clohisey, Sara, Bush, Stephen J., Rojo, Rocío, Lisowski, Zofia M., Wallace, Robert, Grabert, Kathleen, Upton, Kyle R., Tsai, Yi Ting, Brown, Deborah, Smith, Lee B., Summers, Kim M., Mabbott, Neil A., Piccardo, Pedro, Cheeseman, Michael T., Burdon, Tom, Hume, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AAI 2018
Materias:
Immune System Development
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196293/
https://www.ncbi.nlm.nih.gov/pubmed/30249809
http://dx.doi.org/10.4049/jimmunol.1701783

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