Recombinant PAPP-A resistant insulin-like growth factor binding protein 4 (dBP4) inhibits angiogenesis and metastasis in a murine model of breast cancer

BACKGROUND: The Insulin-like growth factor (IGF) pathway plays a role in tumour development and progression. In vivo, IGF1 activity is regulated by the IGF binding proteins (IGFBPs). IGFBP4 inhibits the activity of IGF1 but proteolytic cleavage by pregnancy-associated plasma protein-A (PAPP-A) relea...

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Detalles Bibliográficos
Autores principales: Smith, Y. E., Toomey, S., Napoletano, S., Kirwan, G., Schadow, C., Chubb, A. J., Mikkelsen, J. H., Oxvig, C., Harmey, J. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196427/
https://www.ncbi.nlm.nih.gov/pubmed/30348128
http://dx.doi.org/10.1186/s12885-018-4950-0

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