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Association between the intima-media thickness of the extracranial carotid arteries and metabolic syndrome in ethnic Kyrgyzs

BACKGROUND: It is known that atherosclerosis is the leading cause of cardiovascular disease. We aimed to study the correlation between components of metabolic syndrome (MS) and subclinical carotid atherosclerosis in a group of ethnic Kyrgyzs. METHODS: In а descriptive study we assessed 144 ethnic Ky...

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Autores principales: Kerimkulova, Alina S., Lunegova, Olga S., Mirrakhimov, Aibek E., Abilova, Saamay S., Nabiev, Malik P., Neronova, Ksenia V., Bektasheva, Erkaiym E., Toktomamatov, Ulan M., Esenbekova, Jyldyz E., Mirrakhimov, Erkin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196436/
https://www.ncbi.nlm.nih.gov/pubmed/30348085
http://dx.doi.org/10.1186/s12872-018-0935-9
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author Kerimkulova, Alina S.
Lunegova, Olga S.
Mirrakhimov, Aibek E.
Abilova, Saamay S.
Nabiev, Malik P.
Neronova, Ksenia V.
Bektasheva, Erkaiym E.
Toktomamatov, Ulan M.
Esenbekova, Jyldyz E.
Mirrakhimov, Erkin M.
author_facet Kerimkulova, Alina S.
Lunegova, Olga S.
Mirrakhimov, Aibek E.
Abilova, Saamay S.
Nabiev, Malik P.
Neronova, Ksenia V.
Bektasheva, Erkaiym E.
Toktomamatov, Ulan M.
Esenbekova, Jyldyz E.
Mirrakhimov, Erkin M.
author_sort Kerimkulova, Alina S.
collection PubMed
description BACKGROUND: It is known that atherosclerosis is the leading cause of cardiovascular disease. We aimed to study the correlation between components of metabolic syndrome (MS) and subclinical carotid atherosclerosis in a group of ethnic Kyrgyzs. METHODS: In а descriptive study we assessed 144 ethnic Kyrgyzs (69 males, 75 females) aged 36–73 years (average age 51.03 ± 8.2). All participants underwent a clinical investigation and an anthropometric evaluation (weight, height, waist circumference (WC)). Abdominal obesity (АО) was confirmed at WC ≥ 94 cm in males and ≥ 88 cm in females. Fasting plasma glucose and lipid spectrum tests were performed. An ultrasound assessment of carotid intima-media thickness (IMT) was performed using a 7.5 MHz transducer (Phillips-SD 800). RESULTS: MS was revealed in 61 (42.4%; 47.8% in men and 37.3% in women) of the investigated patients. IMT was significantly increased with the presence of MS components in males (no components vs 2 components of MS: 0.67 ± 0.007 and 0.81 ± 0.009 respectively; р < 0.05) and females (no components vs 3 components of MS: 0.63 ± 0.007 and 0.76 ± 0.01 respectively; р < 0.01). IMT trended towards an increase in the presence of a greater number of MS components in patients with and without AO (р < 0.01). In order to identify independent factors affecting IMT we carried out a multifactorial logistic regression analysis. Arterial hypertension was found to have the greatest influence on the development of MS (OR = 3.81, p < 0.0001). CONCLUSION: In the group of ethnic Kyrgyzs, a greater number of MS components, with AO or without AO, is associated with higher carotid IMT.
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spelling pubmed-61964362018-10-30 Association between the intima-media thickness of the extracranial carotid arteries and metabolic syndrome in ethnic Kyrgyzs Kerimkulova, Alina S. Lunegova, Olga S. Mirrakhimov, Aibek E. Abilova, Saamay S. Nabiev, Malik P. Neronova, Ksenia V. Bektasheva, Erkaiym E. Toktomamatov, Ulan M. Esenbekova, Jyldyz E. Mirrakhimov, Erkin M. BMC Cardiovasc Disord Research Article BACKGROUND: It is known that atherosclerosis is the leading cause of cardiovascular disease. We aimed to study the correlation between components of metabolic syndrome (MS) and subclinical carotid atherosclerosis in a group of ethnic Kyrgyzs. METHODS: In а descriptive study we assessed 144 ethnic Kyrgyzs (69 males, 75 females) aged 36–73 years (average age 51.03 ± 8.2). All participants underwent a clinical investigation and an anthropometric evaluation (weight, height, waist circumference (WC)). Abdominal obesity (АО) was confirmed at WC ≥ 94 cm in males and ≥ 88 cm in females. Fasting plasma glucose and lipid spectrum tests were performed. An ultrasound assessment of carotid intima-media thickness (IMT) was performed using a 7.5 MHz transducer (Phillips-SD 800). RESULTS: MS was revealed in 61 (42.4%; 47.8% in men and 37.3% in women) of the investigated patients. IMT was significantly increased with the presence of MS components in males (no components vs 2 components of MS: 0.67 ± 0.007 and 0.81 ± 0.009 respectively; р < 0.05) and females (no components vs 3 components of MS: 0.63 ± 0.007 and 0.76 ± 0.01 respectively; р < 0.01). IMT trended towards an increase in the presence of a greater number of MS components in patients with and without AO (р < 0.01). In order to identify independent factors affecting IMT we carried out a multifactorial logistic regression analysis. Arterial hypertension was found to have the greatest influence on the development of MS (OR = 3.81, p < 0.0001). CONCLUSION: In the group of ethnic Kyrgyzs, a greater number of MS components, with AO or without AO, is associated with higher carotid IMT. BioMed Central 2018-10-22 /pmc/articles/PMC6196436/ /pubmed/30348085 http://dx.doi.org/10.1186/s12872-018-0935-9 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Kerimkulova, Alina S.
Lunegova, Olga S.
Mirrakhimov, Aibek E.
Abilova, Saamay S.
Nabiev, Malik P.
Neronova, Ksenia V.
Bektasheva, Erkaiym E.
Toktomamatov, Ulan M.
Esenbekova, Jyldyz E.
Mirrakhimov, Erkin M.
Association between the intima-media thickness of the extracranial carotid arteries and metabolic syndrome in ethnic Kyrgyzs
title Association between the intima-media thickness of the extracranial carotid arteries and metabolic syndrome in ethnic Kyrgyzs
title_full Association between the intima-media thickness of the extracranial carotid arteries and metabolic syndrome in ethnic Kyrgyzs
title_fullStr Association between the intima-media thickness of the extracranial carotid arteries and metabolic syndrome in ethnic Kyrgyzs
title_full_unstemmed Association between the intima-media thickness of the extracranial carotid arteries and metabolic syndrome in ethnic Kyrgyzs
title_short Association between the intima-media thickness of the extracranial carotid arteries and metabolic syndrome in ethnic Kyrgyzs
title_sort association between the intima-media thickness of the extracranial carotid arteries and metabolic syndrome in ethnic kyrgyzs
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196436/
https://www.ncbi.nlm.nih.gov/pubmed/30348085
http://dx.doi.org/10.1186/s12872-018-0935-9
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