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Allosteric potentiation of a ligand-gated ion channel is mediated by access to a deep membrane-facing cavity
Theories of general anesthesia have shifted in focus from bulk lipid effects to specific interactions with membrane proteins. Target receptors include several subtypes of pentameric ligand-gated ion channels; however, structures of physiologically relevant proteins in this family have yet to define...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196478/ https://www.ncbi.nlm.nih.gov/pubmed/30275330 http://dx.doi.org/10.1073/pnas.1809650115 |