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Expression of B7 Homolog 1 (B7H1) Is Associated with Clinicopathologic Features in Urothelial Bladder Cancer

BACKGROUND: B7 homolog 1 (B7H1) plays an important role in regulating tumor immunity. The purpose of this study was to probe the relationship between B7H1 expression and clinical outcomes in urothelial bladder cancer. MATERIAL/METHODS: We investigated 110 urothelial bladder cancer cases. The express...

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Autores principales: Li, Qingyuan, Li, Feng, Che, Jizhong, Zhao, Yang, Qiao, Chengjian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196594/
https://www.ncbi.nlm.nih.gov/pubmed/30315148
http://dx.doi.org/10.12659/MSM.910956
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author Li, Qingyuan
Li, Feng
Che, Jizhong
Zhao, Yang
Qiao, Chengjian
author_facet Li, Qingyuan
Li, Feng
Che, Jizhong
Zhao, Yang
Qiao, Chengjian
author_sort Li, Qingyuan
collection PubMed
description BACKGROUND: B7 homolog 1 (B7H1) plays an important role in regulating tumor immunity. The purpose of this study was to probe the relationship between B7H1 expression and clinical outcomes in urothelial bladder cancer. MATERIAL/METHODS: We investigated 110 urothelial bladder cancer cases. The expressions of B7H1 in tumors were analyzed by immunohistochemistry and RT-PCR. The correlation between B7H1 expression and survival rate was analyzed by log-rank test. RESULTS: B7H1 expression was significantly increased in cancerous tissues compared to normal tissues (p<0.05). B7H1 expression was not associated with sex, age, diameter, or the combination of these factors (p>0.05). The positive expression of B7-H1 was positively correlated with grade, stage, recurrence, and metastasis (p<0.05). The RT-PCR results were consistent with the immunohistochemistry outcomes. Furthermore, the expression of B7H1 in tumors was highly correlated with the survival rate (p<0.05). CONCLUSIONS: Expression of B7H1 is correlated with clinicopathologic features in bladder cancer. Up-regulation of B7H1 can result in progression and recurrence of urothelial bladder cancer.
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spelling pubmed-61965942018-10-25 Expression of B7 Homolog 1 (B7H1) Is Associated with Clinicopathologic Features in Urothelial Bladder Cancer Li, Qingyuan Li, Feng Che, Jizhong Zhao, Yang Qiao, Chengjian Med Sci Monit Clinical Research BACKGROUND: B7 homolog 1 (B7H1) plays an important role in regulating tumor immunity. The purpose of this study was to probe the relationship between B7H1 expression and clinical outcomes in urothelial bladder cancer. MATERIAL/METHODS: We investigated 110 urothelial bladder cancer cases. The expressions of B7H1 in tumors were analyzed by immunohistochemistry and RT-PCR. The correlation between B7H1 expression and survival rate was analyzed by log-rank test. RESULTS: B7H1 expression was significantly increased in cancerous tissues compared to normal tissues (p<0.05). B7H1 expression was not associated with sex, age, diameter, or the combination of these factors (p>0.05). The positive expression of B7-H1 was positively correlated with grade, stage, recurrence, and metastasis (p<0.05). The RT-PCR results were consistent with the immunohistochemistry outcomes. Furthermore, the expression of B7H1 in tumors was highly correlated with the survival rate (p<0.05). CONCLUSIONS: Expression of B7H1 is correlated with clinicopathologic features in bladder cancer. Up-regulation of B7H1 can result in progression and recurrence of urothelial bladder cancer. International Scientific Literature, Inc. 2018-10-13 /pmc/articles/PMC6196594/ /pubmed/30315148 http://dx.doi.org/10.12659/MSM.910956 Text en © Med Sci Monit, 2018 This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) )
spellingShingle Clinical Research
Li, Qingyuan
Li, Feng
Che, Jizhong
Zhao, Yang
Qiao, Chengjian
Expression of B7 Homolog 1 (B7H1) Is Associated with Clinicopathologic Features in Urothelial Bladder Cancer
title Expression of B7 Homolog 1 (B7H1) Is Associated with Clinicopathologic Features in Urothelial Bladder Cancer
title_full Expression of B7 Homolog 1 (B7H1) Is Associated with Clinicopathologic Features in Urothelial Bladder Cancer
title_fullStr Expression of B7 Homolog 1 (B7H1) Is Associated with Clinicopathologic Features in Urothelial Bladder Cancer
title_full_unstemmed Expression of B7 Homolog 1 (B7H1) Is Associated with Clinicopathologic Features in Urothelial Bladder Cancer
title_short Expression of B7 Homolog 1 (B7H1) Is Associated with Clinicopathologic Features in Urothelial Bladder Cancer
title_sort expression of b7 homolog 1 (b7h1) is associated with clinicopathologic features in urothelial bladder cancer
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196594/
https://www.ncbi.nlm.nih.gov/pubmed/30315148
http://dx.doi.org/10.12659/MSM.910956
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