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Expression of B7 Homolog 1 (B7H1) Is Associated with Clinicopathologic Features in Urothelial Bladder Cancer
BACKGROUND: B7 homolog 1 (B7H1) plays an important role in regulating tumor immunity. The purpose of this study was to probe the relationship between B7H1 expression and clinical outcomes in urothelial bladder cancer. MATERIAL/METHODS: We investigated 110 urothelial bladder cancer cases. The express...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scientific Literature, Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196594/ https://www.ncbi.nlm.nih.gov/pubmed/30315148 http://dx.doi.org/10.12659/MSM.910956 |
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author | Li, Qingyuan Li, Feng Che, Jizhong Zhao, Yang Qiao, Chengjian |
author_facet | Li, Qingyuan Li, Feng Che, Jizhong Zhao, Yang Qiao, Chengjian |
author_sort | Li, Qingyuan |
collection | PubMed |
description | BACKGROUND: B7 homolog 1 (B7H1) plays an important role in regulating tumor immunity. The purpose of this study was to probe the relationship between B7H1 expression and clinical outcomes in urothelial bladder cancer. MATERIAL/METHODS: We investigated 110 urothelial bladder cancer cases. The expressions of B7H1 in tumors were analyzed by immunohistochemistry and RT-PCR. The correlation between B7H1 expression and survival rate was analyzed by log-rank test. RESULTS: B7H1 expression was significantly increased in cancerous tissues compared to normal tissues (p<0.05). B7H1 expression was not associated with sex, age, diameter, or the combination of these factors (p>0.05). The positive expression of B7-H1 was positively correlated with grade, stage, recurrence, and metastasis (p<0.05). The RT-PCR results were consistent with the immunohistochemistry outcomes. Furthermore, the expression of B7H1 in tumors was highly correlated with the survival rate (p<0.05). CONCLUSIONS: Expression of B7H1 is correlated with clinicopathologic features in bladder cancer. Up-regulation of B7H1 can result in progression and recurrence of urothelial bladder cancer. |
format | Online Article Text |
id | pubmed-6196594 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | International Scientific Literature, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-61965942018-10-25 Expression of B7 Homolog 1 (B7H1) Is Associated with Clinicopathologic Features in Urothelial Bladder Cancer Li, Qingyuan Li, Feng Che, Jizhong Zhao, Yang Qiao, Chengjian Med Sci Monit Clinical Research BACKGROUND: B7 homolog 1 (B7H1) plays an important role in regulating tumor immunity. The purpose of this study was to probe the relationship between B7H1 expression and clinical outcomes in urothelial bladder cancer. MATERIAL/METHODS: We investigated 110 urothelial bladder cancer cases. The expressions of B7H1 in tumors were analyzed by immunohistochemistry and RT-PCR. The correlation between B7H1 expression and survival rate was analyzed by log-rank test. RESULTS: B7H1 expression was significantly increased in cancerous tissues compared to normal tissues (p<0.05). B7H1 expression was not associated with sex, age, diameter, or the combination of these factors (p>0.05). The positive expression of B7-H1 was positively correlated with grade, stage, recurrence, and metastasis (p<0.05). The RT-PCR results were consistent with the immunohistochemistry outcomes. Furthermore, the expression of B7H1 in tumors was highly correlated with the survival rate (p<0.05). CONCLUSIONS: Expression of B7H1 is correlated with clinicopathologic features in bladder cancer. Up-regulation of B7H1 can result in progression and recurrence of urothelial bladder cancer. International Scientific Literature, Inc. 2018-10-13 /pmc/articles/PMC6196594/ /pubmed/30315148 http://dx.doi.org/10.12659/MSM.910956 Text en © Med Sci Monit, 2018 This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) ) |
spellingShingle | Clinical Research Li, Qingyuan Li, Feng Che, Jizhong Zhao, Yang Qiao, Chengjian Expression of B7 Homolog 1 (B7H1) Is Associated with Clinicopathologic Features in Urothelial Bladder Cancer |
title | Expression of B7 Homolog 1 (B7H1) Is Associated with Clinicopathologic Features in Urothelial Bladder Cancer |
title_full | Expression of B7 Homolog 1 (B7H1) Is Associated with Clinicopathologic Features in Urothelial Bladder Cancer |
title_fullStr | Expression of B7 Homolog 1 (B7H1) Is Associated with Clinicopathologic Features in Urothelial Bladder Cancer |
title_full_unstemmed | Expression of B7 Homolog 1 (B7H1) Is Associated with Clinicopathologic Features in Urothelial Bladder Cancer |
title_short | Expression of B7 Homolog 1 (B7H1) Is Associated with Clinicopathologic Features in Urothelial Bladder Cancer |
title_sort | expression of b7 homolog 1 (b7h1) is associated with clinicopathologic features in urothelial bladder cancer |
topic | Clinical Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196594/ https://www.ncbi.nlm.nih.gov/pubmed/30315148 http://dx.doi.org/10.12659/MSM.910956 |
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