Genetic fine mapping of systemic lupus erythematosus MHC associations in Europeans and African Americans

Genetic variation within the major histocompatibility complex (MHC) contributes substantial risk for systemic lupus erythematosus, but high gene density, extreme polymorphism and extensive linkage disequilibrium (LD) have made fine mapping challenging. To address the problem, we compared two associa...

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Detalles Bibliográficos
Autores principales: Hanscombe, Ken B, Morris, David L, Noble, Janelle A, Dilthey, Alexander T, Tombleson, Philip, Kaufman, Kenneth M, Comeau, Mary, Langefeld, Carl D, Alarcon-Riquelme, Marta E, Gaffney, Patrick M, Jacob, Chaim O, Sivils, Kathy L, Tsao, Betty P, Alarcon, Graciela S, Brown, Elizabeth E, Croker, Jennifer, Edberg, Jeff, Gilkeson, Gary, James, Judith A, Kamen, Diane L, Kelly, Jennifer A, McCune, Joseph, Merrill, Joan T, Petri, Michelle, Ramsey-Goldman, Rosalind, Reveille, John D, Salmon, Jane E, Scofield, Hal, Utset, Tammy, Wallace, Daniel J, Weisman, Michael H, Kimberly, Robert P, Harley, John B, Lewis, Cathryn M, Criswell, Lindsey A, Vyse, Timothy J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Association Studies Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196648/
https://www.ncbi.nlm.nih.gov/pubmed/30085094
http://dx.doi.org/10.1093/hmg/ddy280

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