Light‐Driven Enzymatic Decarboxylation of Fatty Acids

The photoenzymatic decarboxylation of fatty acids to alkanes is proposed as an alternative approach for the synthesis of biodiesel. By using a recently discovered photodecarboxylase from Chlorella variabilis NC64A (CvFAP) we demonstrate the irreversible preparation of alkanes from fatty acids and tr...

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Autores principales: Huijbers, Mieke M. E., Zhang, Wuyuan, Tonin, Fabio, Hollmann, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197046/
https://www.ncbi.nlm.nih.gov/pubmed/30106504
http://dx.doi.org/10.1002/anie.201807119
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author Huijbers, Mieke M. E.
Zhang, Wuyuan
Tonin, Fabio
Hollmann, Frank
author_facet Huijbers, Mieke M. E.
Zhang, Wuyuan
Tonin, Fabio
Hollmann, Frank
author_sort Huijbers, Mieke M. E.
collection PubMed
description The photoenzymatic decarboxylation of fatty acids to alkanes is proposed as an alternative approach for the synthesis of biodiesel. By using a recently discovered photodecarboxylase from Chlorella variabilis NC64A (CvFAP) we demonstrate the irreversible preparation of alkanes from fatty acids and triglycerides. Several fatty acids and their triglycerides are converted by CvFAP in near‐quantitative yield and exclusive selectivity upon illumination with blue light. Very promising turnover numbers of up to 8000 were achieved in this proof‐of‐concept study.
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spelling pubmed-61970462018-10-31 Light‐Driven Enzymatic Decarboxylation of Fatty Acids Huijbers, Mieke M. E. Zhang, Wuyuan Tonin, Fabio Hollmann, Frank Angew Chem Int Ed Engl Communications The photoenzymatic decarboxylation of fatty acids to alkanes is proposed as an alternative approach for the synthesis of biodiesel. By using a recently discovered photodecarboxylase from Chlorella variabilis NC64A (CvFAP) we demonstrate the irreversible preparation of alkanes from fatty acids and triglycerides. Several fatty acids and their triglycerides are converted by CvFAP in near‐quantitative yield and exclusive selectivity upon illumination with blue light. Very promising turnover numbers of up to 8000 were achieved in this proof‐of‐concept study. John Wiley and Sons Inc. 2018-09-12 2018-10-08 /pmc/articles/PMC6197046/ /pubmed/30106504 http://dx.doi.org/10.1002/anie.201807119 Text en © 2018 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Communications
Huijbers, Mieke M. E.
Zhang, Wuyuan
Tonin, Fabio
Hollmann, Frank
Light‐Driven Enzymatic Decarboxylation of Fatty Acids
title Light‐Driven Enzymatic Decarboxylation of Fatty Acids
title_full Light‐Driven Enzymatic Decarboxylation of Fatty Acids
title_fullStr Light‐Driven Enzymatic Decarboxylation of Fatty Acids
title_full_unstemmed Light‐Driven Enzymatic Decarboxylation of Fatty Acids
title_short Light‐Driven Enzymatic Decarboxylation of Fatty Acids
title_sort light‐driven enzymatic decarboxylation of fatty acids
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197046/
https://www.ncbi.nlm.nih.gov/pubmed/30106504
http://dx.doi.org/10.1002/anie.201807119
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AT zhangwuyuan lightdrivenenzymaticdecarboxylationoffattyacids
AT toninfabio lightdrivenenzymaticdecarboxylationoffattyacids
AT hollmannfrank lightdrivenenzymaticdecarboxylationoffattyacids

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