Analytical data supporting the “theoretical” postmortem redistribution factor (F(t)): a new model to evaluate postmortem redistribution

The concepts of postmortem redistribution (PMR, F) factor, and “theoretical” PMR (F(t)) – based upon a drug's characteristic L/P ratio – have been defined to express the direct relationship between postmortem peripheral blood and the corresponding antemortem whole-blood concentration. This pape...

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Autor principal: McIntyre, Iain M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197142/
https://www.ncbi.nlm.nih.gov/pubmed/30483608
http://dx.doi.org/10.1080/20961790.2016.1253255
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author McIntyre, Iain M.
author_facet McIntyre, Iain M.
author_sort McIntyre, Iain M.
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description The concepts of postmortem redistribution (PMR, F) factor, and “theoretical” PMR (F(t)) – based upon a drug's characteristic L/P ratio – have been defined to express the direct relationship between postmortem peripheral blood and the corresponding antemortem whole-blood concentration. This paper applies recent data describing liver/peripheral blood (L/P) ratios for many commonly detected drugs to assess these models, and provide a ranking of drugs’ propensity for (and degree of) PMR.
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spelling pubmed-61971422018-11-27 Analytical data supporting the “theoretical” postmortem redistribution factor (F(t)): a new model to evaluate postmortem redistribution McIntyre, Iain M. Forensic Sci Res Articles The concepts of postmortem redistribution (PMR, F) factor, and “theoretical” PMR (F(t)) – based upon a drug's characteristic L/P ratio – have been defined to express the direct relationship between postmortem peripheral blood and the corresponding antemortem whole-blood concentration. This paper applies recent data describing liver/peripheral blood (L/P) ratios for many commonly detected drugs to assess these models, and provide a ranking of drugs’ propensity for (and degree of) PMR. Taylor & Francis 2016-12-16 /pmc/articles/PMC6197142/ /pubmed/30483608 http://dx.doi.org/10.1080/20961790.2016.1253255 Text en © 2016 The Author(s). Published by Taylor & Francis Group on behalf of the Institute of Forensic Science, Ministry of Justice, People's Republic of China http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Articles
McIntyre, Iain M.
Analytical data supporting the “theoretical” postmortem redistribution factor (F(t)): a new model to evaluate postmortem redistribution
title Analytical data supporting the “theoretical” postmortem redistribution factor (F(t)): a new model to evaluate postmortem redistribution
title_full Analytical data supporting the “theoretical” postmortem redistribution factor (F(t)): a new model to evaluate postmortem redistribution
title_fullStr Analytical data supporting the “theoretical” postmortem redistribution factor (F(t)): a new model to evaluate postmortem redistribution
title_full_unstemmed Analytical data supporting the “theoretical” postmortem redistribution factor (F(t)): a new model to evaluate postmortem redistribution
title_short Analytical data supporting the “theoretical” postmortem redistribution factor (F(t)): a new model to evaluate postmortem redistribution
title_sort analytical data supporting the “theoretical” postmortem redistribution factor (f(t)): a new model to evaluate postmortem redistribution
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197142/
https://www.ncbi.nlm.nih.gov/pubmed/30483608
http://dx.doi.org/10.1080/20961790.2016.1253255
work_keys_str_mv AT mcintyreiainm analyticaldatasupportingthetheoreticalpostmortemredistributionfactorftanewmodeltoevaluatepostmortemredistribution

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