microRNA-205-5p is a modulator of insulin sensitivity that inhibits FOXO function

OBJECTIVES: Hepatic insulin resistance is a hallmark of type 2 diabetes and obesity. Insulin receptor signaling through AKT and FOXO has important metabolic effects that have traditionally been ascribed to regulation of gene expression. However, whether all the metabolic effects of FOXO arise from i...

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Detalles Bibliográficos
Autores principales: Langlet, Fanny, Tarbier, Marcel, Haeusler, Rebecca A., Camastra, Stefania, Ferrannini, Eleuterio, Friedländer, Marc R., Accili, Domenico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197154/
https://www.ncbi.nlm.nih.gov/pubmed/30174230
http://dx.doi.org/10.1016/j.molmet.2018.08.003

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