APP promotes osteoblast survival and bone formation by regulating mitochondrial function and preventing oxidative stress

Amyloid precursor protein (APP) is ubiquitously expressed in various types of cells including bone cells. Mutations in App gene result in early-onset Alzheimer’s disease (AD). However, little is known about its physiological function in bone homeostasis. Here, we provide evidence for APP’s role in p...

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Detalles Bibliográficos
Autores principales: Pan, Jin-Xiu, Tang, Fulei, Xiong, Fei, Xiong, Lei, Zeng, Peng, Wang, Bo, Zhao, Kai, Guo, Haohan, Shun, Cui, Xia, Wen-Fang, Mei, Lin, Xiong, Wen-Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197195/
https://www.ncbi.nlm.nih.gov/pubmed/30349052
http://dx.doi.org/10.1038/s41419-018-1123-7

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