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Computational analysis of ligand–receptor interactions in wild-type and mutant erythropoietin complexes
BACKGROUND: Erythropoietin (EPO), a pleiotropic cytokine, binds to its receptor (EPOR) in bone marrow, activating a signaling cascade that results in red blood cell proliferation. A recently discovered naturally occurring EPO mutation (R150Q) at active site 1 (AS1) of the protein was shown to attenu...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Dove Medical Press
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197206/ https://www.ncbi.nlm.nih.gov/pubmed/30410371 http://dx.doi.org/10.2147/AABC.S177206 |