Gene expression dataset for whole cochlea of Macaca fascicularis
Macaca fascicularis is a highly advantageous model in which to study human cochlea with regard to both evolutionary proximity and physiological similarity of the auditory system. To better understand the properties of primate cochlear function, we analyzed the genes predominantly expressed in M. fas...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197234/ https://www.ncbi.nlm.nih.gov/pubmed/30349143 http://dx.doi.org/10.1038/s41598-018-33985-9 |
_version_ | 1783364720638558208 |
---|---|
author | Mutai, Hideki Miya, Fuyuki Shibata, Hiroaki Yasutomi, Yasuhiro Tsunoda, Tatsuhiko Matsunaga, Tatsuo |
author_facet | Mutai, Hideki Miya, Fuyuki Shibata, Hiroaki Yasutomi, Yasuhiro Tsunoda, Tatsuhiko Matsunaga, Tatsuo |
author_sort | Mutai, Hideki |
collection | PubMed |
description | Macaca fascicularis is a highly advantageous model in which to study human cochlea with regard to both evolutionary proximity and physiological similarity of the auditory system. To better understand the properties of primate cochlear function, we analyzed the genes predominantly expressed in M. fascicularis cochlea. We compared the cochlear transcripts obtained from an adult male M. fascicularis by macaque and human GeneChip microarrays with those in multiple macaque and human tissues or cells and identified 344 genes with expression levels more than 2-fold greater than in the other tissues. These “cochlear signature genes” included 35 genes responsible for syndromic or nonsyndromic hereditary hearing loss. Gene set enrichment analysis revealed groups of genes categorized as “ear development” and “ear morphogenesis” in the top 20 gene ontology categories in the macaque and human arrays, respectively. This dataset will facilitate both the study of genes that contribute to primate cochlear function and provide insight to discover novel genes associated with hereditary hearing loss that have yet to be established using animal models. |
format | Online Article Text |
id | pubmed-6197234 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-61972342018-10-24 Gene expression dataset for whole cochlea of Macaca fascicularis Mutai, Hideki Miya, Fuyuki Shibata, Hiroaki Yasutomi, Yasuhiro Tsunoda, Tatsuhiko Matsunaga, Tatsuo Sci Rep Article Macaca fascicularis is a highly advantageous model in which to study human cochlea with regard to both evolutionary proximity and physiological similarity of the auditory system. To better understand the properties of primate cochlear function, we analyzed the genes predominantly expressed in M. fascicularis cochlea. We compared the cochlear transcripts obtained from an adult male M. fascicularis by macaque and human GeneChip microarrays with those in multiple macaque and human tissues or cells and identified 344 genes with expression levels more than 2-fold greater than in the other tissues. These “cochlear signature genes” included 35 genes responsible for syndromic or nonsyndromic hereditary hearing loss. Gene set enrichment analysis revealed groups of genes categorized as “ear development” and “ear morphogenesis” in the top 20 gene ontology categories in the macaque and human arrays, respectively. This dataset will facilitate both the study of genes that contribute to primate cochlear function and provide insight to discover novel genes associated with hereditary hearing loss that have yet to be established using animal models. Nature Publishing Group UK 2018-10-22 /pmc/articles/PMC6197234/ /pubmed/30349143 http://dx.doi.org/10.1038/s41598-018-33985-9 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Mutai, Hideki Miya, Fuyuki Shibata, Hiroaki Yasutomi, Yasuhiro Tsunoda, Tatsuhiko Matsunaga, Tatsuo Gene expression dataset for whole cochlea of Macaca fascicularis |
title | Gene expression dataset for whole cochlea of Macaca fascicularis |
title_full | Gene expression dataset for whole cochlea of Macaca fascicularis |
title_fullStr | Gene expression dataset for whole cochlea of Macaca fascicularis |
title_full_unstemmed | Gene expression dataset for whole cochlea of Macaca fascicularis |
title_short | Gene expression dataset for whole cochlea of Macaca fascicularis |
title_sort | gene expression dataset for whole cochlea of macaca fascicularis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197234/ https://www.ncbi.nlm.nih.gov/pubmed/30349143 http://dx.doi.org/10.1038/s41598-018-33985-9 |
work_keys_str_mv | AT mutaihideki geneexpressiondatasetforwholecochleaofmacacafascicularis AT miyafuyuki geneexpressiondatasetforwholecochleaofmacacafascicularis AT shibatahiroaki geneexpressiondatasetforwholecochleaofmacacafascicularis AT yasutomiyasuhiro geneexpressiondatasetforwholecochleaofmacacafascicularis AT tsunodatatsuhiko geneexpressiondatasetforwholecochleaofmacacafascicularis AT matsunagatatsuo geneexpressiondatasetforwholecochleaofmacacafascicularis |