Gene expression dataset for whole cochlea of Macaca fascicularis

Macaca fascicularis is a highly advantageous model in which to study human cochlea with regard to both evolutionary proximity and physiological similarity of the auditory system. To better understand the properties of primate cochlear function, we analyzed the genes predominantly expressed in M. fas...

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Autores principales: Mutai, Hideki, Miya, Fuyuki, Shibata, Hiroaki, Yasutomi, Yasuhiro, Tsunoda, Tatsuhiko, Matsunaga, Tatsuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197234/
https://www.ncbi.nlm.nih.gov/pubmed/30349143
http://dx.doi.org/10.1038/s41598-018-33985-9
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author Mutai, Hideki
Miya, Fuyuki
Shibata, Hiroaki
Yasutomi, Yasuhiro
Tsunoda, Tatsuhiko
Matsunaga, Tatsuo
author_facet Mutai, Hideki
Miya, Fuyuki
Shibata, Hiroaki
Yasutomi, Yasuhiro
Tsunoda, Tatsuhiko
Matsunaga, Tatsuo
author_sort Mutai, Hideki
collection PubMed
description Macaca fascicularis is a highly advantageous model in which to study human cochlea with regard to both evolutionary proximity and physiological similarity of the auditory system. To better understand the properties of primate cochlear function, we analyzed the genes predominantly expressed in M. fascicularis cochlea. We compared the cochlear transcripts obtained from an adult male M. fascicularis by macaque and human GeneChip microarrays with those in multiple macaque and human tissues or cells and identified 344 genes with expression levels more than 2-fold greater than in the other tissues. These “cochlear signature genes” included 35 genes responsible for syndromic or nonsyndromic hereditary hearing loss. Gene set enrichment analysis revealed groups of genes categorized as “ear development” and “ear morphogenesis” in the top 20 gene ontology categories in the macaque and human arrays, respectively. This dataset will facilitate both the study of genes that contribute to primate cochlear function and provide insight to discover novel genes associated with hereditary hearing loss that have yet to be established using animal models.
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spelling pubmed-61972342018-10-24 Gene expression dataset for whole cochlea of Macaca fascicularis Mutai, Hideki Miya, Fuyuki Shibata, Hiroaki Yasutomi, Yasuhiro Tsunoda, Tatsuhiko Matsunaga, Tatsuo Sci Rep Article Macaca fascicularis is a highly advantageous model in which to study human cochlea with regard to both evolutionary proximity and physiological similarity of the auditory system. To better understand the properties of primate cochlear function, we analyzed the genes predominantly expressed in M. fascicularis cochlea. We compared the cochlear transcripts obtained from an adult male M. fascicularis by macaque and human GeneChip microarrays with those in multiple macaque and human tissues or cells and identified 344 genes with expression levels more than 2-fold greater than in the other tissues. These “cochlear signature genes” included 35 genes responsible for syndromic or nonsyndromic hereditary hearing loss. Gene set enrichment analysis revealed groups of genes categorized as “ear development” and “ear morphogenesis” in the top 20 gene ontology categories in the macaque and human arrays, respectively. This dataset will facilitate both the study of genes that contribute to primate cochlear function and provide insight to discover novel genes associated with hereditary hearing loss that have yet to be established using animal models. Nature Publishing Group UK 2018-10-22 /pmc/articles/PMC6197234/ /pubmed/30349143 http://dx.doi.org/10.1038/s41598-018-33985-9 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Mutai, Hideki
Miya, Fuyuki
Shibata, Hiroaki
Yasutomi, Yasuhiro
Tsunoda, Tatsuhiko
Matsunaga, Tatsuo
Gene expression dataset for whole cochlea of Macaca fascicularis
title Gene expression dataset for whole cochlea of Macaca fascicularis
title_full Gene expression dataset for whole cochlea of Macaca fascicularis
title_fullStr Gene expression dataset for whole cochlea of Macaca fascicularis
title_full_unstemmed Gene expression dataset for whole cochlea of Macaca fascicularis
title_short Gene expression dataset for whole cochlea of Macaca fascicularis
title_sort gene expression dataset for whole cochlea of macaca fascicularis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197234/
https://www.ncbi.nlm.nih.gov/pubmed/30349143
http://dx.doi.org/10.1038/s41598-018-33985-9
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