Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1

The tumor suppressor and deubiquitinase (DUB) BAP1 and its Drosophila ortholog Calypso assemble DUB complexes with the transcription regulators Additional sex combs-like (ASXL1, ASXL2, ASXL3) and Asx respectively. ASXLs and Asx use their DEUBiquitinase ADaptor (DEUBAD) domain to stimulate BAP1/Calyp...

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Detalles Bibliográficos
Autores principales: Daou, Salima, Barbour, Haithem, Ahmed, Oumaima, Masclef, Louis, Baril, Caroline, Sen Nkwe, Nadine, Tchelougou, Daméhan, Uriarte, Maxime, Bonneil, Eric, Ceccarelli, Derek, Mashtalir, Nazar, Tanji, Mika, Masson, Jean-Yves, Thibault, Pierre, Sicheri, Frank, Yang, Haining, Carbone, Michele, Therrien, Marc, Affar, El Bachir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197237/
https://www.ncbi.nlm.nih.gov/pubmed/30349006
http://dx.doi.org/10.1038/s41467-018-06854-2

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