PDL1 is expressed in the islets of people with type 1 diabetes and is up-regulated by interferons-α and-γ via IRF1 induction

BACKGROUND: Antibodies targeting PD-1 and its ligand PDL1 are used in cancer immunotherapy but may lead to autoimmune diseases, including type 1 diabetes (T1D). It remains unclear whether PDL1 is expressed in pancreatic islets of people with T1D and how is it regulated. METHODS: The expression of PD...

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Detalles Bibliográficos
Autores principales: Colli, Maikel L., Hill, Jessica L.E., Marroquí, Laura, Chaffey, Jessica, Dos Santos, Reinaldo S., Leete, Pia, Coomans de Brachène, Alexandra, Paula, Flavia M.M., Op de Beeck, Anne, Castela, Angela, Marselli, Lorella, Krogvold, Lars, Dahl-Jorgensen, Knut, Marchetti, Piero, Morgan, Noel G., Richardson, Sarah J., Eizirik, Décio L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197434/
https://www.ncbi.nlm.nih.gov/pubmed/30269996
http://dx.doi.org/10.1016/j.ebiom.2018.09.040

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197434/
https://www.ncbi.nlm.nih.gov/pubmed/30269996
http://dx.doi.org/10.1016/j.ebiom.2018.09.040

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