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Subcortical brain volumes, cortical thickness and cortical surface area in families genetically enriched for social anxiety disorder – A multiplex multigenerational neuroimaging study

BACKGROUND: Social anxiety disorder (SAD) is a disabling psychiatric condition with a genetic background. Brain alterations in gray matter (GM) related to SAD have been previously reported, but it remains to be elucidated whether GM measures are candidate endophenotypes of SAD. Endophenotypes are me...

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Autores principales: Bas-Hoogendam, Janna Marie, van Steenbergen, Henk, Tissier, Renaud L.M., Houwing-Duistermaat, Jeanine J., Westenberg, P.Michiel, van der Wee, Nic J.A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197574/
https://www.ncbi.nlm.nih.gov/pubmed/30266294
http://dx.doi.org/10.1016/j.ebiom.2018.08.048
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author Bas-Hoogendam, Janna Marie
van Steenbergen, Henk
Tissier, Renaud L.M.
Houwing-Duistermaat, Jeanine J.
Westenberg, P.Michiel
van der Wee, Nic J.A.
author_facet Bas-Hoogendam, Janna Marie
van Steenbergen, Henk
Tissier, Renaud L.M.
Houwing-Duistermaat, Jeanine J.
Westenberg, P.Michiel
van der Wee, Nic J.A.
author_sort Bas-Hoogendam, Janna Marie
collection PubMed
description BACKGROUND: Social anxiety disorder (SAD) is a disabling psychiatric condition with a genetic background. Brain alterations in gray matter (GM) related to SAD have been previously reported, but it remains to be elucidated whether GM measures are candidate endophenotypes of SAD. Endophenotypes are measurable characteristics on the causal pathway from genotype to phenotype, providing insight in genetically-based disease mechanisms. Based on a review of existing evidence, we examined whether GM characteristics meet two endophenotype criteria, using data from a unique sample of SAD-patients and their family-members of two generations. First, we investigated whether GM characteristics co-segregate with social anxiety within families genetically enriched for SAD. Secondly, heritability of the GM characteristics was estimated. METHODS: Families with a genetic predisposition for SAD participated in the Leiden Family Lab study on SAD; T1-weighted MRI brain scans were acquired (n = 110, 8 families). Subcortical volumes, cortical thickness and cortical surface area were determined for a-priori determined regions of interest (ROIs). Next, associations with social anxiety and heritabilities were estimated. FINDINGS: Several subcortical and cortical GM characteristics, derived from frontal, parietal and temporal ROIs, co-segregated with social anxiety within families (uncorrected p-level) and showed moderate to high heritability. INTERPRETATION: These findings provide preliminary evidence that GM characteristics of multiple ROIs, which are distributed over the brain, are candidate endophenotypes of SAD. Thereby, they shed light on the genetic vulnerability for SAD. Future research is needed to confirm these results and to link them to functional brain alterations and to genetic variations underlying these GM changes. FUND: Leiden University Research Profile ‘Health, Prevention and the Human Life Cycle’.
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spelling pubmed-61975742018-10-24 Subcortical brain volumes, cortical thickness and cortical surface area in families genetically enriched for social anxiety disorder – A multiplex multigenerational neuroimaging study Bas-Hoogendam, Janna Marie van Steenbergen, Henk Tissier, Renaud L.M. Houwing-Duistermaat, Jeanine J. Westenberg, P.Michiel van der Wee, Nic J.A. EBioMedicine Research paper BACKGROUND: Social anxiety disorder (SAD) is a disabling psychiatric condition with a genetic background. Brain alterations in gray matter (GM) related to SAD have been previously reported, but it remains to be elucidated whether GM measures are candidate endophenotypes of SAD. Endophenotypes are measurable characteristics on the causal pathway from genotype to phenotype, providing insight in genetically-based disease mechanisms. Based on a review of existing evidence, we examined whether GM characteristics meet two endophenotype criteria, using data from a unique sample of SAD-patients and their family-members of two generations. First, we investigated whether GM characteristics co-segregate with social anxiety within families genetically enriched for SAD. Secondly, heritability of the GM characteristics was estimated. METHODS: Families with a genetic predisposition for SAD participated in the Leiden Family Lab study on SAD; T1-weighted MRI brain scans were acquired (n = 110, 8 families). Subcortical volumes, cortical thickness and cortical surface area were determined for a-priori determined regions of interest (ROIs). Next, associations with social anxiety and heritabilities were estimated. FINDINGS: Several subcortical and cortical GM characteristics, derived from frontal, parietal and temporal ROIs, co-segregated with social anxiety within families (uncorrected p-level) and showed moderate to high heritability. INTERPRETATION: These findings provide preliminary evidence that GM characteristics of multiple ROIs, which are distributed over the brain, are candidate endophenotypes of SAD. Thereby, they shed light on the genetic vulnerability for SAD. Future research is needed to confirm these results and to link them to functional brain alterations and to genetic variations underlying these GM changes. FUND: Leiden University Research Profile ‘Health, Prevention and the Human Life Cycle’. Elsevier 2018-09-25 /pmc/articles/PMC6197574/ /pubmed/30266294 http://dx.doi.org/10.1016/j.ebiom.2018.08.048 Text en © 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research paper
Bas-Hoogendam, Janna Marie
van Steenbergen, Henk
Tissier, Renaud L.M.
Houwing-Duistermaat, Jeanine J.
Westenberg, P.Michiel
van der Wee, Nic J.A.
Subcortical brain volumes, cortical thickness and cortical surface area in families genetically enriched for social anxiety disorder – A multiplex multigenerational neuroimaging study
title Subcortical brain volumes, cortical thickness and cortical surface area in families genetically enriched for social anxiety disorder – A multiplex multigenerational neuroimaging study
title_full Subcortical brain volumes, cortical thickness and cortical surface area in families genetically enriched for social anxiety disorder – A multiplex multigenerational neuroimaging study
title_fullStr Subcortical brain volumes, cortical thickness and cortical surface area in families genetically enriched for social anxiety disorder – A multiplex multigenerational neuroimaging study
title_full_unstemmed Subcortical brain volumes, cortical thickness and cortical surface area in families genetically enriched for social anxiety disorder – A multiplex multigenerational neuroimaging study
title_short Subcortical brain volumes, cortical thickness and cortical surface area in families genetically enriched for social anxiety disorder – A multiplex multigenerational neuroimaging study
title_sort subcortical brain volumes, cortical thickness and cortical surface area in families genetically enriched for social anxiety disorder – a multiplex multigenerational neuroimaging study
topic Research paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197574/
https://www.ncbi.nlm.nih.gov/pubmed/30266294
http://dx.doi.org/10.1016/j.ebiom.2018.08.048
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