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Human rhomboid family-1 modulates clathrin coated vesicle-dependent pro-transforming growth factor α membrane trafficking to promote breast cancer progression

BACKGROUND: Epidermal growth factor receptor (EGFR) signalling is critical in epithelial cancer development. Human rhomboid family-1 (RHBDF1) facilitates the secretion of TGFα, an EGFR ligand, in breast cancer; however, the underlying mechanism remains unclear. We evaluated the role for RHBDF1 in cl...

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Detalles Bibliográficos
Autores principales:	Li, Jie, Bai, Tai-Ran, Gao, Shan, Zhou, Zhuan, Peng, Xue-Mei, Zhang, Li-Song, Dou, Dao-Lei, Zhang, Zhi-Song, Li, Lu-Yuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2018
Materias:	Research paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197618/ https://www.ncbi.nlm.nih.gov/pubmed/30279141 http://dx.doi.org/10.1016/j.ebiom.2018.09.038

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