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Suppression of STAT3 signaling promotes cellular reprogramming into insulin-producing cells induced by defined transcription factors

BACKGROUND: STAT3 has been demonstrated to play a role in maintaining cellular identities in the pancreas, whereas an activating STAT3 mutation has been linked to impaired β-cell function. METHODS: The role of STAT3 in β-cell neogenesis, induced by the exogenous expression of Pdx1, Neurog3, and Mafa...

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Detalles Bibliográficos
Autores principales:	Miura, Masaki, Miyatsuka, Takeshi, Katahira, Takehiro, Sasaki, Shugo, Suzuki, Luka, Himuro, Miwa, Nishida, Yuya, Fujitani, Yoshio, Matsuoka, Taka-aki, Watada, Hirotaka
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2018
Materias:	Research paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197741/ https://www.ncbi.nlm.nih.gov/pubmed/30266298 http://dx.doi.org/10.1016/j.ebiom.2018.09.035

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