Triazolo[4,5-d]pyrimidines as Validated General Control Nonderepressible 2 (GCN2) Protein Kinase Inhibitors Reduce Growth of Leukemia Cells

Cellular stress signals activate adaptive signaling pathways of the mammalian integrated stress response (ISR), of which the unfolded protein response (UPR) is a subset. These pathways converge at the phosporylation of eIF2α. Drug-like, potent and selective chemical inhibitors (valid chemical probes...

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Detalles Bibliográficos
Autores principales: Lough, Lea, Sherman, Dan, Becerra-Flores, Manuel, Vasudevan, Deepika, Lavinda, Olga, Ni, Eric, Wang, Hong, Ryoo, Hyung Don, Tibes, Raoul, Cardozo, Timothy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197744/
https://www.ncbi.nlm.nih.gov/pubmed/30364637
http://dx.doi.org/10.1016/j.csbj.2018.09.003

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