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A PDX1-ATF transcriptional complex governs β cell survival during stress
OBJECTIVE: Loss of insulin secretion due to failure or death of the insulin secreting β cells is the central cause of diabetes. The cellular response to stress (endoplasmic reticulum (ER), oxidative, inflammatory) is essential to sustain normal β cell function and survival. Pancreatic and duodenal h...
Autores principales: | Juliana, Christine A., Yang, Juxiang, Cannon, Corey E., Good, Austin L., Haemmerle, Matthew W., Stoffers, Doris A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197747/ https://www.ncbi.nlm.nih.gov/pubmed/30174228 http://dx.doi.org/10.1016/j.molmet.2018.07.007 |
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