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Partial reprogramming of heterologous cells by defined factors to generate megakaryocyte lineage-restricted biomolecules
The ability of transcriptional regulators to drive lineage conversion of somatic cells offers great potential for the treatment of human disease. To explore the concept of switching on specific target genes in heterologous cells, we developed a model system to screen candidate factors for their abil...
Autores principales: | Artuz, Crisbel M., Knights, Alexander J., Funnell, Alister P.W., Gonda, Thomas J., Ravid, Katya, Pearson, Richard C.M., Quinlan, Kate G.R., Crossley, Merlin |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197760/ https://www.ncbi.nlm.nih.gov/pubmed/30364711 http://dx.doi.org/10.1016/j.btre.2018.e00285 |
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