Engineering Nanoparticles for Targeted Delivery of Nucleic Acid Therapeutics in Tumor

In the past 10 years, with the increase of investment in clinical nano-gene therapy, there are many trials that have been discontinued due to poor efficacy and serious side effects. Therefore, it is particularly important to design a suitable gene delivery system. In this paper, we introduce the app...

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Detalles Bibliográficos
Autores principales: Xiao, Yao, Shi, Kun, Qu, Ying, Chu, Bingyang, Qian, Zhiyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197778/
https://www.ncbi.nlm.nih.gov/pubmed/30364598
http://dx.doi.org/10.1016/j.omtm.2018.09.002
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author Xiao, Yao
Shi, Kun
Qu, Ying
Chu, Bingyang
Qian, Zhiyong
author_facet Xiao, Yao
Shi, Kun
Qu, Ying
Chu, Bingyang
Qian, Zhiyong
author_sort Xiao, Yao
collection PubMed
description In the past 10 years, with the increase of investment in clinical nano-gene therapy, there are many trials that have been discontinued due to poor efficacy and serious side effects. Therefore, it is particularly important to design a suitable gene delivery system. In this paper, we introduce the application of liposomes, polymers, and inorganics in gene delivery; also, different modifications with some stimuli-responsive systems can effectively improve the efficiency of gene delivery and reduce cytotoxicity and other side effects. Besides, the co-delivery of chemotherapy drugs with a drug tolerance-related gene or oncogene provides a better theoretical basis for clinical cancer gene therapy.
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spelling pubmed-61977782018-10-24 Engineering Nanoparticles for Targeted Delivery of Nucleic Acid Therapeutics in Tumor Xiao, Yao Shi, Kun Qu, Ying Chu, Bingyang Qian, Zhiyong Mol Ther Methods Clin Dev Article In the past 10 years, with the increase of investment in clinical nano-gene therapy, there are many trials that have been discontinued due to poor efficacy and serious side effects. Therefore, it is particularly important to design a suitable gene delivery system. In this paper, we introduce the application of liposomes, polymers, and inorganics in gene delivery; also, different modifications with some stimuli-responsive systems can effectively improve the efficiency of gene delivery and reduce cytotoxicity and other side effects. Besides, the co-delivery of chemotherapy drugs with a drug tolerance-related gene or oncogene provides a better theoretical basis for clinical cancer gene therapy. American Society of Gene & Cell Therapy 2018-09-22 /pmc/articles/PMC6197778/ /pubmed/30364598 http://dx.doi.org/10.1016/j.omtm.2018.09.002 Text en © 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Xiao, Yao
Shi, Kun
Qu, Ying
Chu, Bingyang
Qian, Zhiyong
Engineering Nanoparticles for Targeted Delivery of Nucleic Acid Therapeutics in Tumor
title Engineering Nanoparticles for Targeted Delivery of Nucleic Acid Therapeutics in Tumor
title_full Engineering Nanoparticles for Targeted Delivery of Nucleic Acid Therapeutics in Tumor
title_fullStr Engineering Nanoparticles for Targeted Delivery of Nucleic Acid Therapeutics in Tumor
title_full_unstemmed Engineering Nanoparticles for Targeted Delivery of Nucleic Acid Therapeutics in Tumor
title_short Engineering Nanoparticles for Targeted Delivery of Nucleic Acid Therapeutics in Tumor
title_sort engineering nanoparticles for targeted delivery of nucleic acid therapeutics in tumor
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197778/
https://www.ncbi.nlm.nih.gov/pubmed/30364598
http://dx.doi.org/10.1016/j.omtm.2018.09.002
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