Cargando…

Identification of Novel Cdc7 Kinase Inhibitors as Anti-Cancer Agents that Target the Interaction with Dbf4 by the Fragment Complementation and Drug Repositioning Approach

BACKGROUND: Cdc7-Dbf4 is a conserved serine/threonine kinase that plays an important role in initiation of DNA replication and DNA damage tolerance in eukaryotic cells. Cdc7 has been found overexpressed in human cancer cell lines and tumor tissues, and the knockdown of Cdc7 expression causes an p53-...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cheng, An Ning, Lo, Yu-Kang, Lin, Yi-Sheng, Tang, Tswen-Kei, Hsu, Chun-Hua, Hsu, John T.-A., Lee, Alan Yueh-Luen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2018
Materias:	Research paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197782/ https://www.ncbi.nlm.nih.gov/pubmed/30293817 http://dx.doi.org/10.1016/j.ebiom.2018.09.030

Ejemplares similares

Structural Insight into the MCM double hexamer activation by Dbf4-Cdc7 kinase
por: Cheng, Jiaxuan, et al.
Publicado: (2022)

Author Correction: Structural Insight into the MCM double hexamer activation by Dbf4-Cdc7 kinase
por: Cheng, Jiaxuan, et al.
Publicado: (2022)

Cdc7p-Dbf4p Regulates Mitotic Exit by Inhibiting Polo Kinase
por: Miller, Charles T., et al.
Publicado: (2009)

The Dbf4-Cdc7 kinase promotes S phase by alleviating an inhibitory activity in Mcm4
por: Sheu, Yi-Jun, et al.
Publicado: (2010)

Kinetochores Coordinate Pericentromeric Cohesion and Early DNA Replication by Cdc7-Dbf4 Kinase Recruitment
por: Natsume, Toyoaki, et al.
Publicado: (2013)

The structural basis of Cdc7-Dbf4 kinase dependent targeting and phosphorylation of the MCM2-7 double hexamer
por: Saleh, Almutasem, et al.
Publicado: (2022)

Cdc7-Dbf4-mediated phosphorylation of HSP90-S164 stabilizes HSP90-HCLK2-MRN complex to enhance ATR/ATM signaling that overcomes replication stress in cancer
por: Cheng, An Ning, et al.
Publicado: (2017)

Candida albicans Dbf4-dependent Cdc7 kinase plays a novel role in the inhibition of hyphal development
por: Lai, Wei-Chung, et al.
Publicado: (2016)

Rec8 Phosphorylation by Casein Kinase 1 and Cdc7-Dbf4 Kinase Regulates Cohesin Cleavage by Separase during Meiosis
por: Katis, Vittorio L., et al.
Publicado: (2010)

A Xenopus Dbf4 homolog is required for Cdc7 chromatin binding and DNA replication
por: Jares, Pedro, et al.
Publicado: (2004)

‘AND’ logic gates at work: Crystal structure of Rad53 bound to Dbf4 and Cdc7
por: Almawi, Ahmad W., et al.
Publicado: (2016)

ATR–Chk1–APC/C(Cdh1)-dependent stabilization of Cdc7–ASK (Dbf4) kinase is required for DNA lesion bypass under replication stress
por: Yamada, Masayuki, et al.
Publicado: (2013)

The Potent Cdc7-Dbf4 (DDK) Kinase Inhibitor XL413 Has Limited Activity in Many Cancer Cell Lines and Discovery of Potential New DDK Inhibitor Scaffolds
por: Sasi, Nanda Kumar, et al.
Publicado: (2014)

Dbf2–Mob1 drives relocalization of protein phosphatase Cdc14 to the cytoplasm during exit from mitosis
por: Mohl, Dane A., et al.
Publicado: (2009)

Nuclear DBF-2-related Kinases Are Essential Regulators of Cytokinesis in Bloodstream Stage Trypanosoma brucei
por: Ma, Jiangtao, et al.
Publicado: (2010)

Dbf4-Cdc7 (DDK) Inhibitor PHA-767491 Displays Potent Anti-Proliferative Effects via Crosstalk with the CDK2-RB-E2F Pathway
por: Pauzaite, Tekle, et al.
Publicado: (2022)

Phosphopeptide binding by Sld3 links Dbf4‐dependent kinase to MCM replicative helicase activation
por: Deegan, Tom D, et al.
Publicado: (2016)

Structural mechanism for the selective phosphorylation of DNA-loaded MCM double hexamers by the Dbf4-dependent kinase
por: Greiwe, Julia F., et al.
Publicado: (2021)

Dual function of the NDR-kinase Dbf2 in the regulation of the F-BAR protein Hof1 during cytokinesis
por: Meitinger, Franz, et al.
Publicado: (2013)

Nuclear Dbf2-related Kinase 1 functions as tumor suppressor in glioblastoma by phosphorylation of Yes-associated protein
por: Chen, Bin, et al.
Publicado: (2021)

Substrate specificity analysis of protein kinase complex Dbf2-Mob1 by peptide library and proteome array screening
por: Mah, Angie S, et al.
Publicado: (2005)

Mitotic exit kinase Dbf2 directly phosphorylates chitin synthase Chs2 to regulate cytokinesis in budding yeast
por: Oh, Younghoon, et al.
Publicado: (2012)

Dbf4-Dependent Kinase (DDK)-Mediated Proteolysis of CENP-A Prevents Mislocalization of CENP-A in Saccharomyces cerevisiae
por: Eisenstatt, Jessica R., et al.
Publicado: (2020)

Cdc7 kinase stimulates Aurora B kinase in M-phase
por: Ito, Sayuri, et al.
Publicado: (2019)

Dbf4‐dependent kinase and the Rtt107 scaffold promote Mus81‐Mms4 resolvase activation during mitosis
por: Princz, Lissa N, et al.
Publicado: (2017)

Sld3-MCM Interaction Facilitated by Dbf4-Dependent Kinase Defines an Essential Step in Eukaryotic DNA Replication Initiation
por: Fang, Dingqiang, et al.
Publicado: (2016)

DBF4 Dependent Kinase Inhibition Suppresses Hepatocellular Carcinoma Progression and Potentiates Anti-Programmed Cell Death-1 Therapy
por: Zhang, Liang, et al.
Publicado: (2023)

Interactions of the Human MCM-BP Protein with MCM Complex Components and Dbf4
por: Nguyen, Tin, et al.
Publicado: (2012)

Drug repositioning in drug discovery of T2DM and repositioning potential of antidiabetic agents
por: Zhu, Sha, et al.
Publicado: (2022)

Checkpoint Dependent Inhibition of DNA Replication Initiation by Sld3 and Dbf4 Phosphorylation
por: Zegerman, Philip, et al.
Publicado: (2010)

Cdc6 cooperates with c-Myc to promote genome instability and epithelial to mesenchymal transition (EMT) in zebrafish
por: Chen, Ching-Hung, et al.
Publicado: (2014)

Molecular Mechanism of Biofilm Locator Protein Kinase Dbf2p-related kinase 1 in Regulating Innate Immune Response to Interleukin 17-induced Viral Pneumonia
por: Wang, Haifeng, et al.
Publicado: (2021)

Development of Pigmentation-Regulating Agents by Drug Repositioning
por: Jeong, Seo-Mi-Gon, et al.
Publicado: (2021)

Structural Basis for the Activation and Target Site Specificity of CDC7 Kinase
por: Dick, Samual D., et al.
Publicado: (2020)

The interaction between the Dbf4 ortholog Chiffon and Gcn5 is conserved in Dipteran insect species
por: George, Smitha, et al.
Publicado: (2022)

Claspin recruits Cdc7 kinase for initiation of DNA replication in human cells
por: Yang, Chi-Chun, et al.
Publicado: (2016)

Localization of Cdc7 Protein Kinase During DNA Replication in Saccharomyces cerevisiae
por: Rossbach, Daniel, et al.
Publicado: (2017)

The inferior alveolar nerve at the proximal fragment during bilateral sagittal split osteotomy - Is there need to reposition to distal fragment?
por: Rao, Jingade Krishnojirao Dayashankara
Publicado: (2023)

Pyruvate Kinase M2 serves as blockade for nucleosome repositioning and abrogates Chd7 remodeling activity
por: Verma, Kirtika, et al.
Publicado: (2019)

The Interaction between Circulating Complement Proteins and Cutaneous Microvascular Endothelial Cells in the Development of Childhood Henoch-Schönlein Purpura
por: Yang, Yao-Hsu, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_hs0bkh7tur4v1nla99jv7sbd7r