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Identification of Novel Cdc7 Kinase Inhibitors as Anti-Cancer Agents that Target the Interaction with Dbf4 by the Fragment Complementation and Drug Repositioning Approach

BACKGROUND: Cdc7-Dbf4 is a conserved serine/threonine kinase that plays an important role in initiation of DNA replication and DNA damage tolerance in eukaryotic cells. Cdc7 has been found overexpressed in human cancer cell lines and tumor tissues, and the knockdown of Cdc7 expression causes an p53-...

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Detalles Bibliográficos
Autores principales:	Cheng, An Ning, Lo, Yu-Kang, Lin, Yi-Sheng, Tang, Tswen-Kei, Hsu, Chun-Hua, Hsu, John T.-A., Lee, Alan Yueh-Luen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2018
Materias:	Research paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197782/ https://www.ncbi.nlm.nih.gov/pubmed/30293817 http://dx.doi.org/10.1016/j.ebiom.2018.09.030

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