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Polymorphism Located in the Upstream Region of the RPS19 Gene (rs2305809) Is Associated With Cervical Cancer: A Case-control Study
Cervical cancer (CC) is caused by persistent human papillomavirus (HPV) infection and affects women worldwide. The progression of an HPV persistent infection to CC is influenced by genetic factors. Three single nucleotide polymorphisms (SNPs) in TP53, NQO1 and RPS19 genes (rs1042522, rs1800566, rs23...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Society of Cancer Prevention
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197843/ https://www.ncbi.nlm.nih.gov/pubmed/30370260 http://dx.doi.org/10.15430/JCP.2018.23.3.147 |
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author | da Rocha Boeira, Thaís Coser, Janaina Wolf, Jonas Michel Cardinal, Bruna Klahr Manggini Grivicich, Ivana Simon, Daniel Lunge, Vagner Ricardo |
author_facet | da Rocha Boeira, Thaís Coser, Janaina Wolf, Jonas Michel Cardinal, Bruna Klahr Manggini Grivicich, Ivana Simon, Daniel Lunge, Vagner Ricardo |
author_sort | da Rocha Boeira, Thaís |
collection | PubMed |
description | Cervical cancer (CC) is caused by persistent human papillomavirus (HPV) infection and affects women worldwide. The progression of an HPV persistent infection to CC is influenced by genetic factors. Three single nucleotide polymorphisms (SNPs) in TP53, NQO1 and RPS19 genes (rs1042522, rs1800566, rs2305809, respectively) were previously associated with CC in European and North American populations. The present case-control study aimed to investigate the association of the SNPs rs1042522, rs1800566, and rs2305809 with CC in an admixed population in southern Brazil. A total of 435 women (106 CC patients and 329 controls) were recruited for this study. All women were interviewed and underwent clinical sampling. SNPs rs1042522 and rs1800566 were evaluated by PCR-RFLP. SNP rs2305809 was determined by real-time PCR. The crude and adjusted ORs with 95% CI were estimated. The recessive genetic model (C/C + C/T) for rs2305809 was more frequent in the control group (79.9%) compared to the cases (69.8%), being associated with CC protection ((adjusted)OR = 0.49; 95% CI: 0.27–0.90). However, the other polymorphisms evaluated did not present significant differences between cases and controls. This study detected a protective association for the recessive genetic model in rs2305809. These results suggest a potential role of the RPS19 gene in CC. |
format | Online Article Text |
id | pubmed-6197843 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Korean Society of Cancer Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-61978432018-10-26 Polymorphism Located in the Upstream Region of the RPS19 Gene (rs2305809) Is Associated With Cervical Cancer: A Case-control Study da Rocha Boeira, Thaís Coser, Janaina Wolf, Jonas Michel Cardinal, Bruna Klahr Manggini Grivicich, Ivana Simon, Daniel Lunge, Vagner Ricardo J Cancer Prev Short Communication Cervical cancer (CC) is caused by persistent human papillomavirus (HPV) infection and affects women worldwide. The progression of an HPV persistent infection to CC is influenced by genetic factors. Three single nucleotide polymorphisms (SNPs) in TP53, NQO1 and RPS19 genes (rs1042522, rs1800566, rs2305809, respectively) were previously associated with CC in European and North American populations. The present case-control study aimed to investigate the association of the SNPs rs1042522, rs1800566, and rs2305809 with CC in an admixed population in southern Brazil. A total of 435 women (106 CC patients and 329 controls) were recruited for this study. All women were interviewed and underwent clinical sampling. SNPs rs1042522 and rs1800566 were evaluated by PCR-RFLP. SNP rs2305809 was determined by real-time PCR. The crude and adjusted ORs with 95% CI were estimated. The recessive genetic model (C/C + C/T) for rs2305809 was more frequent in the control group (79.9%) compared to the cases (69.8%), being associated with CC protection ((adjusted)OR = 0.49; 95% CI: 0.27–0.90). However, the other polymorphisms evaluated did not present significant differences between cases and controls. This study detected a protective association for the recessive genetic model in rs2305809. These results suggest a potential role of the RPS19 gene in CC. Korean Society of Cancer Prevention 2018-09 2018-09-30 /pmc/articles/PMC6197843/ /pubmed/30370260 http://dx.doi.org/10.15430/JCP.2018.23.3.147 Text en Copyright © 2018 Korean Society of Cancer Prevention This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Communication da Rocha Boeira, Thaís Coser, Janaina Wolf, Jonas Michel Cardinal, Bruna Klahr Manggini Grivicich, Ivana Simon, Daniel Lunge, Vagner Ricardo Polymorphism Located in the Upstream Region of the RPS19 Gene (rs2305809) Is Associated With Cervical Cancer: A Case-control Study |
title | Polymorphism Located in the Upstream Region of the RPS19 Gene (rs2305809) Is Associated With Cervical Cancer: A Case-control Study |
title_full | Polymorphism Located in the Upstream Region of the RPS19 Gene (rs2305809) Is Associated With Cervical Cancer: A Case-control Study |
title_fullStr | Polymorphism Located in the Upstream Region of the RPS19 Gene (rs2305809) Is Associated With Cervical Cancer: A Case-control Study |
title_full_unstemmed | Polymorphism Located in the Upstream Region of the RPS19 Gene (rs2305809) Is Associated With Cervical Cancer: A Case-control Study |
title_short | Polymorphism Located in the Upstream Region of the RPS19 Gene (rs2305809) Is Associated With Cervical Cancer: A Case-control Study |
title_sort | polymorphism located in the upstream region of the rps19 gene (rs2305809) is associated with cervical cancer: a case-control study |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197843/ https://www.ncbi.nlm.nih.gov/pubmed/30370260 http://dx.doi.org/10.15430/JCP.2018.23.3.147 |
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