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The past, present and future of light-gated ion channels and optogenetics

The discovery of the mechanisms underlying light-gated ion channels called channelrhodospins and the subsequent development of optogenetics illustrates how breakthroughs in science and technology can span multiple levels of scientific inquiry. Our knowledge of how channelrhodopsins work emerged from...

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Autor principal: Josselyn, Sheena A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197853/
https://www.ncbi.nlm.nih.gov/pubmed/30343681
http://dx.doi.org/10.7554/eLife.42367
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author Josselyn, Sheena A
author_facet Josselyn, Sheena A
author_sort Josselyn, Sheena A
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description The discovery of the mechanisms underlying light-gated ion channels called channelrhodospins and the subsequent development of optogenetics illustrates how breakthroughs in science and technology can span multiple levels of scientific inquiry. Our knowledge of how channelrhodopsins work emerged from research at the microscopic level that investigated the structure and function of algal proteins. Optogenetics, on the other hand, exploits the power of channelrhodospins and similar proteins to investigate phenomena at the supra-macroscopic level, notably the neural circuits involved in animal behavior that may be relevant for understanding neuropsychiatric disease. This article is being published to celebrate Peter Hegemann, Karl Deisseroth and Ed Boyden receiving a 2018 Canada Gairdner International Award "for the discovery of light-gated ion channel mechanisms, and for the discovery of optogenetics, a technology that has revolutionized neuroscience".
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spelling pubmed-61978532018-10-24 The past, present and future of light-gated ion channels and optogenetics Josselyn, Sheena A eLife Cell Biology The discovery of the mechanisms underlying light-gated ion channels called channelrhodospins and the subsequent development of optogenetics illustrates how breakthroughs in science and technology can span multiple levels of scientific inquiry. Our knowledge of how channelrhodopsins work emerged from research at the microscopic level that investigated the structure and function of algal proteins. Optogenetics, on the other hand, exploits the power of channelrhodospins and similar proteins to investigate phenomena at the supra-macroscopic level, notably the neural circuits involved in animal behavior that may be relevant for understanding neuropsychiatric disease. This article is being published to celebrate Peter Hegemann, Karl Deisseroth and Ed Boyden receiving a 2018 Canada Gairdner International Award "for the discovery of light-gated ion channel mechanisms, and for the discovery of optogenetics, a technology that has revolutionized neuroscience". eLife Sciences Publications, Ltd 2018-10-22 /pmc/articles/PMC6197853/ /pubmed/30343681 http://dx.doi.org/10.7554/eLife.42367 Text en © 2018, Josselyn http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Cell Biology
Josselyn, Sheena A
The past, present and future of light-gated ion channels and optogenetics
title The past, present and future of light-gated ion channels and optogenetics
title_full The past, present and future of light-gated ion channels and optogenetics
title_fullStr The past, present and future of light-gated ion channels and optogenetics
title_full_unstemmed The past, present and future of light-gated ion channels and optogenetics
title_short The past, present and future of light-gated ion channels and optogenetics
title_sort past, present and future of light-gated ion channels and optogenetics
topic Cell Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197853/
https://www.ncbi.nlm.nih.gov/pubmed/30343681
http://dx.doi.org/10.7554/eLife.42367
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