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Chromatin Regulation by HP1γ Contributes to Survival of 5-Azacytidine-Resistant Cells

Recent investigations of the treatment for hematologic neoplasms have focused on targeting epigenetic regulators. The DNA methyltransferase inhibitor 5-azacytidine (AZA) has produced good results in the treatment of patients with myelodysplastic syndromes. The mechanism underlying its pharmacologica...

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Detalles Bibliográficos
Autores principales:	Imanishi, Satoshi, Umezu, Tomohiro, Kobayashi, Chiaki, Ohta, Tomohiko, Ohyashiki, Kazuma, Ohyashiki, Junko H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198088/ https://www.ncbi.nlm.nih.gov/pubmed/30386240 http://dx.doi.org/10.3389/fphar.2018.01166

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