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Prospective memory impairment following whole brain radiotherapy in patients with metastatic brain cancer
OBJECTIVE: To investigate the prospective memory (PM) impairment following whole brain radiotherapy (WBRT) in cancer patients with brain metastases. METHOD: Eighty‐one patients with metastatic brain cancer, agreeing to undergo WBRT, were enrolled and subjected to a battery of cognitive neuropsycholo...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198199/ https://www.ncbi.nlm.nih.gov/pubmed/30259694 http://dx.doi.org/10.1002/cam4.1784 |
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author | Cheng, Huaidong Chen, Haijun Lv, Yue Chen, Zhendong Li, Chiang‐Shan R. |
author_facet | Cheng, Huaidong Chen, Haijun Lv, Yue Chen, Zhendong Li, Chiang‐Shan R. |
author_sort | Cheng, Huaidong |
collection | PubMed |
description | OBJECTIVE: To investigate the prospective memory (PM) impairment following whole brain radiotherapy (WBRT) in cancer patients with brain metastases. METHOD: Eighty‐one patients with metastatic brain cancer, agreeing to undergo WBRT, were enrolled and subjected to a battery of cognitive neuropsychological tests, including the mini‐mental state examination (MMSE), verbal fluency test (VFT), digit span test (DST), and event‐based and time‐based prospective memory (EBPM and TBPM) tasks, before and after radiotherapy. RESULTS: The patients with metastatic brain cancer after WBRT exhibited a significant decrease in the MMSE, DST, VFT, and EBPM scores (t = 6.258, 10.192, 5.361, −5.892, P < 0.01), but nonsignificant decrease in the TBPM scores (t = −1.172, P > 0.05). CONCLUSION: There is significant EBPM impairment in cancer patients with brain metastases after WBRT, whereas that in the TBPM remained relatively unaffected. The result suggests that EBPM impairment may be as an early cognitive impairment marker in patients with BM who undergo WBRT. |
format | Online Article Text |
id | pubmed-6198199 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-61981992018-10-31 Prospective memory impairment following whole brain radiotherapy in patients with metastatic brain cancer Cheng, Huaidong Chen, Haijun Lv, Yue Chen, Zhendong Li, Chiang‐Shan R. Cancer Med Cancer Prevention OBJECTIVE: To investigate the prospective memory (PM) impairment following whole brain radiotherapy (WBRT) in cancer patients with brain metastases. METHOD: Eighty‐one patients with metastatic brain cancer, agreeing to undergo WBRT, were enrolled and subjected to a battery of cognitive neuropsychological tests, including the mini‐mental state examination (MMSE), verbal fluency test (VFT), digit span test (DST), and event‐based and time‐based prospective memory (EBPM and TBPM) tasks, before and after radiotherapy. RESULTS: The patients with metastatic brain cancer after WBRT exhibited a significant decrease in the MMSE, DST, VFT, and EBPM scores (t = 6.258, 10.192, 5.361, −5.892, P < 0.01), but nonsignificant decrease in the TBPM scores (t = −1.172, P > 0.05). CONCLUSION: There is significant EBPM impairment in cancer patients with brain metastases after WBRT, whereas that in the TBPM remained relatively unaffected. The result suggests that EBPM impairment may be as an early cognitive impairment marker in patients with BM who undergo WBRT. John Wiley and Sons Inc. 2018-09-27 /pmc/articles/PMC6198199/ /pubmed/30259694 http://dx.doi.org/10.1002/cam4.1784 Text en © 2018 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Cancer Prevention Cheng, Huaidong Chen, Haijun Lv, Yue Chen, Zhendong Li, Chiang‐Shan R. Prospective memory impairment following whole brain radiotherapy in patients with metastatic brain cancer |
title | Prospective memory impairment following whole brain radiotherapy in patients with metastatic brain cancer |
title_full | Prospective memory impairment following whole brain radiotherapy in patients with metastatic brain cancer |
title_fullStr | Prospective memory impairment following whole brain radiotherapy in patients with metastatic brain cancer |
title_full_unstemmed | Prospective memory impairment following whole brain radiotherapy in patients with metastatic brain cancer |
title_short | Prospective memory impairment following whole brain radiotherapy in patients with metastatic brain cancer |
title_sort | prospective memory impairment following whole brain radiotherapy in patients with metastatic brain cancer |
topic | Cancer Prevention |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198199/ https://www.ncbi.nlm.nih.gov/pubmed/30259694 http://dx.doi.org/10.1002/cam4.1784 |
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