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Prospective memory impairment following whole brain radiotherapy in patients with metastatic brain cancer

OBJECTIVE: To investigate the prospective memory (PM) impairment following whole brain radiotherapy (WBRT) in cancer patients with brain metastases. METHOD: Eighty‐one patients with metastatic brain cancer, agreeing to undergo WBRT, were enrolled and subjected to a battery of cognitive neuropsycholo...

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Autores principales: Cheng, Huaidong, Chen, Haijun, Lv, Yue, Chen, Zhendong, Li, Chiang‐Shan R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198199/
https://www.ncbi.nlm.nih.gov/pubmed/30259694
http://dx.doi.org/10.1002/cam4.1784
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author Cheng, Huaidong
Chen, Haijun
Lv, Yue
Chen, Zhendong
Li, Chiang‐Shan R.
author_facet Cheng, Huaidong
Chen, Haijun
Lv, Yue
Chen, Zhendong
Li, Chiang‐Shan R.
author_sort Cheng, Huaidong
collection PubMed
description OBJECTIVE: To investigate the prospective memory (PM) impairment following whole brain radiotherapy (WBRT) in cancer patients with brain metastases. METHOD: Eighty‐one patients with metastatic brain cancer, agreeing to undergo WBRT, were enrolled and subjected to a battery of cognitive neuropsychological tests, including the mini‐mental state examination (MMSE), verbal fluency test (VFT), digit span test (DST), and event‐based and time‐based prospective memory (EBPM and TBPM) tasks, before and after radiotherapy. RESULTS: The patients with metastatic brain cancer after WBRT exhibited a significant decrease in the MMSE, DST, VFT, and EBPM scores (t = 6.258, 10.192, 5.361, −5.892, P < 0.01), but nonsignificant decrease in the TBPM scores (t = −1.172, P > 0.05). CONCLUSION: There is significant EBPM impairment in cancer patients with brain metastases after WBRT, whereas that in the TBPM remained relatively unaffected. The result suggests that EBPM impairment may be as an early cognitive impairment marker in patients with BM who undergo WBRT.
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spelling pubmed-61981992018-10-31 Prospective memory impairment following whole brain radiotherapy in patients with metastatic brain cancer Cheng, Huaidong Chen, Haijun Lv, Yue Chen, Zhendong Li, Chiang‐Shan R. Cancer Med Cancer Prevention OBJECTIVE: To investigate the prospective memory (PM) impairment following whole brain radiotherapy (WBRT) in cancer patients with brain metastases. METHOD: Eighty‐one patients with metastatic brain cancer, agreeing to undergo WBRT, were enrolled and subjected to a battery of cognitive neuropsychological tests, including the mini‐mental state examination (MMSE), verbal fluency test (VFT), digit span test (DST), and event‐based and time‐based prospective memory (EBPM and TBPM) tasks, before and after radiotherapy. RESULTS: The patients with metastatic brain cancer after WBRT exhibited a significant decrease in the MMSE, DST, VFT, and EBPM scores (t = 6.258, 10.192, 5.361, −5.892, P < 0.01), but nonsignificant decrease in the TBPM scores (t = −1.172, P > 0.05). CONCLUSION: There is significant EBPM impairment in cancer patients with brain metastases after WBRT, whereas that in the TBPM remained relatively unaffected. The result suggests that EBPM impairment may be as an early cognitive impairment marker in patients with BM who undergo WBRT. John Wiley and Sons Inc. 2018-09-27 /pmc/articles/PMC6198199/ /pubmed/30259694 http://dx.doi.org/10.1002/cam4.1784 Text en © 2018 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Cancer Prevention
Cheng, Huaidong
Chen, Haijun
Lv, Yue
Chen, Zhendong
Li, Chiang‐Shan R.
Prospective memory impairment following whole brain radiotherapy in patients with metastatic brain cancer
title Prospective memory impairment following whole brain radiotherapy in patients with metastatic brain cancer
title_full Prospective memory impairment following whole brain radiotherapy in patients with metastatic brain cancer
title_fullStr Prospective memory impairment following whole brain radiotherapy in patients with metastatic brain cancer
title_full_unstemmed Prospective memory impairment following whole brain radiotherapy in patients with metastatic brain cancer
title_short Prospective memory impairment following whole brain radiotherapy in patients with metastatic brain cancer
title_sort prospective memory impairment following whole brain radiotherapy in patients with metastatic brain cancer
topic Cancer Prevention
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198199/
https://www.ncbi.nlm.nih.gov/pubmed/30259694
http://dx.doi.org/10.1002/cam4.1784
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