Chemical Instability and Promiscuity of Arylmethylidenepyrazolinone-Based MDMX Inhibitors

[Image: see text] Targeting the protein–protein interaction between p53 and MDM2/MDMX (MDM4) represents an attractive anticancer strategy for the treatment of p53-competent tumors. Several selective and potent MDM2 inhibitors have been developed and entered the clinic; however, the repertoire of MDM...

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Detalles Bibliográficos
Autores principales: Stefaniak, Jakub, Lewis, Andrew M., Conole, Daniel, Galan, Sébastien R. G., Bataille, Carole J. R., Wynne, Graham M., Castaldi, M. Paola, Lundbäck, Thomas, Russell, Angela J., Huber, Kilian V. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198280/
https://www.ncbi.nlm.nih.gov/pubmed/30216042
http://dx.doi.org/10.1021/acschembio.8b00665

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