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Kawasaki disease: two case reports from the Aga Khan Hospital, Dar es Salaam-Tanzania

BACKGROUND: Kawasaki disease is a common childhood vasculitis which may result in cardiovascular morbidity if not adequately treated. Its epidemiology in the African region is not well described. Its features may mimic other childhood infections and hemoglobinopathies and it is rarely diagnosed in t...

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Autores principales: Noorani, Mariam, Lakhani, Nuruddin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198366/
https://www.ncbi.nlm.nih.gov/pubmed/30352566
http://dx.doi.org/10.1186/s12887-018-1306-5
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author Noorani, Mariam
Lakhani, Nuruddin
author_facet Noorani, Mariam
Lakhani, Nuruddin
author_sort Noorani, Mariam
collection PubMed
description BACKGROUND: Kawasaki disease is a common childhood vasculitis which may result in cardiovascular morbidity if not adequately treated. Its epidemiology in the African region is not well described. Its features may mimic other childhood infections and hemoglobinopathies and it is rarely diagnosed in the East African region. These are the first reports of this disease from Tanzania. CASE PRESENTATION: We present two cases of complete Kawasaki disease seen over a 2 year period and diagnosed as per the criteria defined by the American Heart Association. One child was and infant and the other a 3 year old. Both of them presented with a prolonged fever and mucocutaneous findings. None of the children developed coronary artery aneurysms. One was treated with aspirin alone and the other with both aspirin and intravenous immunoglobulin. Both children had complete recovery and did not have any cardiovascular sequelae. CONCLUSION: Kawasaki disease may be more common in the East African region than previously thought. It should be considered as a differential diagnosis in children who present with a prolonged fever of greater than 5 days and mucocutaneous findings. More awareness about this condition, its epidemiology, diagnosis and management are required in order to prevent the cardiovascular morbidity associated with it.
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spelling pubmed-61983662018-10-30 Kawasaki disease: two case reports from the Aga Khan Hospital, Dar es Salaam-Tanzania Noorani, Mariam Lakhani, Nuruddin BMC Pediatr Case Report BACKGROUND: Kawasaki disease is a common childhood vasculitis which may result in cardiovascular morbidity if not adequately treated. Its epidemiology in the African region is not well described. Its features may mimic other childhood infections and hemoglobinopathies and it is rarely diagnosed in the East African region. These are the first reports of this disease from Tanzania. CASE PRESENTATION: We present two cases of complete Kawasaki disease seen over a 2 year period and diagnosed as per the criteria defined by the American Heart Association. One child was and infant and the other a 3 year old. Both of them presented with a prolonged fever and mucocutaneous findings. None of the children developed coronary artery aneurysms. One was treated with aspirin alone and the other with both aspirin and intravenous immunoglobulin. Both children had complete recovery and did not have any cardiovascular sequelae. CONCLUSION: Kawasaki disease may be more common in the East African region than previously thought. It should be considered as a differential diagnosis in children who present with a prolonged fever of greater than 5 days and mucocutaneous findings. More awareness about this condition, its epidemiology, diagnosis and management are required in order to prevent the cardiovascular morbidity associated with it. BioMed Central 2018-10-23 /pmc/articles/PMC6198366/ /pubmed/30352566 http://dx.doi.org/10.1186/s12887-018-1306-5 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Noorani, Mariam
Lakhani, Nuruddin
Kawasaki disease: two case reports from the Aga Khan Hospital, Dar es Salaam-Tanzania
title Kawasaki disease: two case reports from the Aga Khan Hospital, Dar es Salaam-Tanzania
title_full Kawasaki disease: two case reports from the Aga Khan Hospital, Dar es Salaam-Tanzania
title_fullStr Kawasaki disease: two case reports from the Aga Khan Hospital, Dar es Salaam-Tanzania
title_full_unstemmed Kawasaki disease: two case reports from the Aga Khan Hospital, Dar es Salaam-Tanzania
title_short Kawasaki disease: two case reports from the Aga Khan Hospital, Dar es Salaam-Tanzania
title_sort kawasaki disease: two case reports from the aga khan hospital, dar es salaam-tanzania
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198366/
https://www.ncbi.nlm.nih.gov/pubmed/30352566
http://dx.doi.org/10.1186/s12887-018-1306-5
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