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Innate immune activation of astrocytes impairs neurodevelopment via upregulation of follistatin-like 1 and interferon-induced transmembrane protein 3

BACKGROUND: Polyriboinosinic-polyribocytidylic acid (polyI:C) triggers a strong innate immune response that mimics immune activation by viral infections. Induction of interferon-induced transmembrane protein 3 (Ifitm3) in astrocytes has a crucial role in polyI:C-induced neurodevelopmental abnormalit...

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Detalles Bibliográficos
Autores principales:	Yamada, Shinnosuke, Itoh, Norimichi, Nagai, Taku, Nakai, Tsuyoshi, Ibi, Daisuke, Nakajima, Akira, Nabeshima, Toshitaka, Yamada, Kiyofumi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198367/ https://www.ncbi.nlm.nih.gov/pubmed/30348171 http://dx.doi.org/10.1186/s12974-018-1332-0

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