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Reactive plasmacytosis mimicking multiple myeloma associated with SFTS virus infection: a report of two cases and literature review
BACKGROUND: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by a novel bunyavirus named SFTS virus (SFTSV), which is classified into the genus Phlebovirus and family Phenuiviridae. Reactive plasmacytosis mimicking multiple myeloma is a very rare condition...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198377/ https://www.ncbi.nlm.nih.gov/pubmed/30348099 http://dx.doi.org/10.1186/s12879-018-3431-z |
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author | Zhang, Jinjing Yan, Xiaojing Li, Yan Gao, Ran Wang, Pingping Mo, Wenbin |
author_facet | Zhang, Jinjing Yan, Xiaojing Li, Yan Gao, Ran Wang, Pingping Mo, Wenbin |
author_sort | Zhang, Jinjing |
collection | PubMed |
description | BACKGROUND: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by a novel bunyavirus named SFTS virus (SFTSV), which is classified into the genus Phlebovirus and family Phenuiviridae. Reactive plasmacytosis mimicking multiple myeloma is a very rare condition in association with SFTS. Here, we describe two SFTS cases who presented with hyperimmunoglobulinemia, as well as extensive bone marrow and peripheral blood plasmacytosis, which mimicked multiple myeloma (MM). CASE PRESENTATION: We report two cases who presented with fever and blood routine abnormity which were conformed as SFTS eventually. They were performed bone marrow aspiration and were admitted to the department of hematology with a preliminary diagnosis of MM. They all had hyperimmunoglobulinemia, extensive bone marrow and peripheral blood plasma cells, prolonged activated partial thromboplastin time (APTT), elevated hepatic enzyme. The two patients recovered with treatment of doxycycline, human immunoglobulins, plasma transfusion, and other supporting treatments. But case 1 occurred lymphoma 8 months later and died. CONCLUSION: SFTS might be one of differential diagnosis of MM in certain endemic area. We also conclude that SFTSV is a pantropic virus that could injure most tissues and cells of the human body. |
format | Online Article Text |
id | pubmed-6198377 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-61983772018-10-31 Reactive plasmacytosis mimicking multiple myeloma associated with SFTS virus infection: a report of two cases and literature review Zhang, Jinjing Yan, Xiaojing Li, Yan Gao, Ran Wang, Pingping Mo, Wenbin BMC Infect Dis Case Report BACKGROUND: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by a novel bunyavirus named SFTS virus (SFTSV), which is classified into the genus Phlebovirus and family Phenuiviridae. Reactive plasmacytosis mimicking multiple myeloma is a very rare condition in association with SFTS. Here, we describe two SFTS cases who presented with hyperimmunoglobulinemia, as well as extensive bone marrow and peripheral blood plasmacytosis, which mimicked multiple myeloma (MM). CASE PRESENTATION: We report two cases who presented with fever and blood routine abnormity which were conformed as SFTS eventually. They were performed bone marrow aspiration and were admitted to the department of hematology with a preliminary diagnosis of MM. They all had hyperimmunoglobulinemia, extensive bone marrow and peripheral blood plasma cells, prolonged activated partial thromboplastin time (APTT), elevated hepatic enzyme. The two patients recovered with treatment of doxycycline, human immunoglobulins, plasma transfusion, and other supporting treatments. But case 1 occurred lymphoma 8 months later and died. CONCLUSION: SFTS might be one of differential diagnosis of MM in certain endemic area. We also conclude that SFTSV is a pantropic virus that could injure most tissues and cells of the human body. BioMed Central 2018-10-22 /pmc/articles/PMC6198377/ /pubmed/30348099 http://dx.doi.org/10.1186/s12879-018-3431-z Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Case Report Zhang, Jinjing Yan, Xiaojing Li, Yan Gao, Ran Wang, Pingping Mo, Wenbin Reactive plasmacytosis mimicking multiple myeloma associated with SFTS virus infection: a report of two cases and literature review |
title | Reactive plasmacytosis mimicking multiple myeloma associated with SFTS virus infection: a report of two cases and literature review |
title_full | Reactive plasmacytosis mimicking multiple myeloma associated with SFTS virus infection: a report of two cases and literature review |
title_fullStr | Reactive plasmacytosis mimicking multiple myeloma associated with SFTS virus infection: a report of two cases and literature review |
title_full_unstemmed | Reactive plasmacytosis mimicking multiple myeloma associated with SFTS virus infection: a report of two cases and literature review |
title_short | Reactive plasmacytosis mimicking multiple myeloma associated with SFTS virus infection: a report of two cases and literature review |
title_sort | reactive plasmacytosis mimicking multiple myeloma associated with sfts virus infection: a report of two cases and literature review |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198377/ https://www.ncbi.nlm.nih.gov/pubmed/30348099 http://dx.doi.org/10.1186/s12879-018-3431-z |
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