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The hypermethylation of p16 gene exon 1 and exon 2: potential biomarkers for colorectal cancer and are associated with cancer pathological staging

BACKGROUND: Tumor suppressor gene p16 promoter hypermethylation has been widely studied in colorectal cancer (CRC), yet its clinicopathological significance remains controversial. The methylation alterations of other regions within p16 gene are still rarely researched. The present study aimed to exp...

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Detalles Bibliográficos
Autores principales:	Ye, Xiaoxia, Mo, Mingming, Xu, Simin, Yang, Qingjin, Wu, Minhua, Zhang, Junjie, Chen, Bin, Li, Jian, Zhong, Yu, Huang, Qionglin, Cai, Chun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198490/ https://www.ncbi.nlm.nih.gov/pubmed/30348132 http://dx.doi.org/10.1186/s12885-018-4921-5

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