NMDA receptors mediate synaptic depression, but not spine loss in the dentate gyrus of adult amyloid Beta (Aβ) overexpressing mice

Amyloid beta (Aβ)-mediated synapse dysfunction and spine loss are considered to be early events in Alzheimer’s disease (AD) pathogenesis. N-methyl-D-aspartate receptors (NMDARs) have previously been suggested to play a role for Amyloid beta (Aβ) toxicity. Pharmacological block of NMDAR subunits in c...

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Detalles Bibliográficos
Autores principales: Müller, Michaela Kerstin, Jacobi, Eric, Sakimura, Kenji, Malinow, Roberto, von Engelhardt, Jakob
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198500/
https://www.ncbi.nlm.nih.gov/pubmed/30352630
http://dx.doi.org/10.1186/s40478-018-0611-4

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