Self-consistency test reveals systematic bias in programs for prediction change of stability upon mutation

MOTIVATION: Computational prediction of the effect of mutations on protein stability is used by researchers in many fields. The utility of the prediction methods is affected by their accuracy and bias. Bias, a systematic shift of the predicted change of stability, has been noted as an issue for seve...

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Detalles Bibliográficos
Autores principales: Usmanova, Dinara R, Bogatyreva, Natalya S, Ariño Bernad, Joan, Eremina, Aleksandra A, Gorshkova, Anastasiya A, Kanevskiy, German M, Lonishin, Lyubov R, Meister, Alexander V, Yakupova, Alisa G, Kondrashov, Fyodor A, Ivankov, Dmitry N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198859/
https://www.ncbi.nlm.nih.gov/pubmed/29722803
http://dx.doi.org/10.1093/bioinformatics/bty340

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