The retinoprotective role of phenytoin

Phenytoin is a non-sedative barbiturate derivate and has been recently rediscovered as a neuroprotective and retinoprotective compound in patients affected by optic neuritis secondary to multiple sclerosis. However, currently there are still no neuroprotective compounds registered and available in t...

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Detalles Bibliográficos
Autores principales: Bartollino, Silvia, Chiosi, Flavia, di Staso, Silvio, Uva, Maurizio, Pascotto, Arduino, Rinaldi, Michele, Hesselink, Jan M Keppel, Costagliola, Ciro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198895/
https://www.ncbi.nlm.nih.gov/pubmed/30410309
http://dx.doi.org/10.2147/DDDT.S169621
Descripción
Sumario:Phenytoin is a non-sedative barbiturate derivate and has been recently rediscovered as a neuroprotective and retinoprotective compound in patients affected by optic neuritis secondary to multiple sclerosis. However, currently there are still no neuroprotective compounds registered and available in the clinic. We reviewed the literature supporting the retinoprotective properties of phenytoin and analyzed the various approaches and definitions from the first research periods onwards. The retinoprotective role of phenytoin was already known in the 1970s, but only recently has this effect been rediscovered, confirming that it could indeed provide structural protection of the retinal cells.

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