The retinoprotective role of phenytoin

Phenytoin is a non-sedative barbiturate derivate and has been recently rediscovered as a neuroprotective and retinoprotective compound in patients affected by optic neuritis secondary to multiple sclerosis. However, currently there are still no neuroprotective compounds registered and available in t...

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Autores principales: Bartollino, Silvia, Chiosi, Flavia, di Staso, Silvio, Uva, Maurizio, Pascotto, Arduino, Rinaldi, Michele, Hesselink, Jan M Keppel, Costagliola, Ciro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198895/
https://www.ncbi.nlm.nih.gov/pubmed/30410309
http://dx.doi.org/10.2147/DDDT.S169621
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author Bartollino, Silvia
Chiosi, Flavia
di Staso, Silvio
Uva, Maurizio
Pascotto, Arduino
Rinaldi, Michele
Hesselink, Jan M Keppel
Costagliola, Ciro
author_facet Bartollino, Silvia
Chiosi, Flavia
di Staso, Silvio
Uva, Maurizio
Pascotto, Arduino
Rinaldi, Michele
Hesselink, Jan M Keppel
Costagliola, Ciro
author_sort Bartollino, Silvia
collection PubMed
description Phenytoin is a non-sedative barbiturate derivate and has been recently rediscovered as a neuroprotective and retinoprotective compound in patients affected by optic neuritis secondary to multiple sclerosis. However, currently there are still no neuroprotective compounds registered and available in the clinic. We reviewed the literature supporting the retinoprotective properties of phenytoin and analyzed the various approaches and definitions from the first research periods onwards. The retinoprotective role of phenytoin was already known in the 1970s, but only recently has this effect been rediscovered, confirming that it could indeed provide structural protection of the retinal cells.
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spelling pubmed-61988952018-11-08 The retinoprotective role of phenytoin Bartollino, Silvia Chiosi, Flavia di Staso, Silvio Uva, Maurizio Pascotto, Arduino Rinaldi, Michele Hesselink, Jan M Keppel Costagliola, Ciro Drug Des Devel Ther Review Phenytoin is a non-sedative barbiturate derivate and has been recently rediscovered as a neuroprotective and retinoprotective compound in patients affected by optic neuritis secondary to multiple sclerosis. However, currently there are still no neuroprotective compounds registered and available in the clinic. We reviewed the literature supporting the retinoprotective properties of phenytoin and analyzed the various approaches and definitions from the first research periods onwards. The retinoprotective role of phenytoin was already known in the 1970s, but only recently has this effect been rediscovered, confirming that it could indeed provide structural protection of the retinal cells. Dove Medical Press 2018-10-16 /pmc/articles/PMC6198895/ /pubmed/30410309 http://dx.doi.org/10.2147/DDDT.S169621 Text en © 2018 Bartollino et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Review
Bartollino, Silvia
Chiosi, Flavia
di Staso, Silvio
Uva, Maurizio
Pascotto, Arduino
Rinaldi, Michele
Hesselink, Jan M Keppel
Costagliola, Ciro
The retinoprotective role of phenytoin
title The retinoprotective role of phenytoin
title_full The retinoprotective role of phenytoin
title_fullStr The retinoprotective role of phenytoin
title_full_unstemmed The retinoprotective role of phenytoin
title_short The retinoprotective role of phenytoin
title_sort retinoprotective role of phenytoin
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198895/
https://www.ncbi.nlm.nih.gov/pubmed/30410309
http://dx.doi.org/10.2147/DDDT.S169621
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